Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | APAF1 | O14727 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11492546 | 0.83 | TSHR (0.48) | TSHRNPSR1LMNATP53ALDH1A1 | |
| SCHEMBL11491366 | 0.82 | OPRM1 (0.41) | TSHRNPSR1LMNATP53ALDH1A1 | |
| SCHEMBL8819203 | 0.79 | TSHR (0.71) | TSHRNPSR1LMNATP53ALDH1A1 | |
| SCHEMBL8820471 | 0.78 | TSHR (0.71) | TSHRNPSR1LMNATP53ALDH1A1 | |
| SCHEMBL8819880 | 0.78 | TSHR (0.69) | TSHRNPSR1LMNATP53ALDH1A1 | |
| SCHEMBL15127558 | 0.77 | TSHR (0.65) | TSHRNPSR1LMNATP53ALDH1A1 | |
| SCHEMBL3633383 | 0.76 | TSHR (0.61) | TSHRNPSR1LMNATP53ALDH1A1 | |
| SCHEMBL11492687 | 0.75 | OPRM1 (0.42) | TSHRNPSR1LMNATP53SMN1; SMN2 | |
| SCHEMBL8109277 | 0.75 | TSHR (0.66) | TSHRNPSR1LMNATP53ALDH1A1 | |
| SCHEMBL11484746 | 0.75 | DRD2 (0.41) | TSHRNPSR1LMNATP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4188485-A | NEUROLEPTIC, CORRESPONDING XANTHENES AND THIOANTHENES | G. D. SEARLE & CO. (US) | 1980-02-12 | — | — | US | disclosed |