Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | CHKA | P35790 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5304924 | 0.98 | CHKA (0.49) | LMNAALDH1A1KDM4ERAB9ACHKA | |
| Hydrochloric Acid SCHEMBL10670016 | 0.86 | ALDH1A1 (0.50) | LMNAALDH1A1KDM4ERAB9ACHKA | |
| SCHEMBL31652036 | 0.84 | ACHE (0.48) | LMNAALDH1A1KDM4ERAB9ACHKA | |
| SCHEMBL5288484 | 0.81 | CHKA (0.46) | LMNAALDH1A1KDM4ERAB9ACHKA | |
| Hydrochloric Acid SCHEMBL5155076 | 0.79 | ALDH1A1 (0.61) | LMNAALDH1A1KDM4ERAB9ACHKA | |
| SCHEMBL5295886 | 0.78 | CHKA (0.44) | LMNAALDH1A1KDM4ERAB9ACHKA | |
| SCHEMBL5294209 | 0.78 | CHRNA7 (0.47) | HTTTP53ACHEMEN1KMT2A | |
| SCHEMBL5298333 | 0.77 | HTT (0.42) | LMNAALDH1A1KDM4ERAB9ACHKA | |
| SCHEMBL5304667 | 0.77 | TP53 (0.64) | LMNAALDH1A1KDM4ERAB9ACHKA | |
| SCHEMBL5292346 | 0.76 | HTT (0.42) | LMNAALDH1A1KDM4ERAB9ACHKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4205171-A | ANALGESICS | STERLING DRUG INC. (US) | 1980-05-27 | — | — | US | disclosed |
| US-RE29943-E | ANALGESICS | STERLING DRUG INC. (US) | 1979-03-20 | — | — | US | disclosed |
| US-4127577-A | Aminomethanobenzazocine process | STERLING DRUG INC. (US) | 1978-11-28 | — | — | US | disclosed |
| US-4108857-A | CNS DEPRESSANTS, ANALGESICS, PSYCHOMOTOR ACTION | STERLING DRUG INC. (US) | 1978-08-22 | — | — | US | disclosed |
| US-4032529-A | ANALGESICS | STERLING DRUG INC. (US) | 1977-06-28 | — | — | US | disclosed |
| US-3968114-A | ANALGESIC | STERLING DRUG INC. (US) | 1976-07-06 | — | — | US | disclosed |
| US-3957793-A | ANALGESICS | STERLING DRUG INC. (US) | 1976-05-18 | — | — | US | disclosed |