Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 4/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | MERTK | Q12866 | 2/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3119002 | 0.74 | NPY5R (0.71) | NPY5RMERTKABCG2POLBKMT2A | |
| SCHEMBL2845653 | 0.71 | APP (0.76) | APPMERTKPOLBKMT2APDE5A | |
| SCHEMBL1685041 | 0.71 | APP (0.74) | EGFRAPPPOLBPDE5ALMNA | |
| Hydrochloric Acid SCHEMBL1685081 | 0.70 | APP (0.72) | EGFRAPPPOLBKMT2APDE5A | |
| SCHEMBL25243367 | 0.69 | MAPT (0.67) | APPKMT2AMEN1PDE5ALMNA | |
| SCHEMBL11255646 | 0.69 | GBA1 (0.61) | APPKMT2AMEN1PDE5AACP1 | |
| SCHEMBL11255510 | 0.68 | GBA1 (0.55) | APPPOLBKMT2AMEN1PDE5A | |
| SCHEMBL11246446 | 0.68 | GBA1 (0.54) | APPPOLBKMT2AMEN1PDE5A | |
| SCHEMBL3113616 | 0.67 | MAPT (0.72) | ABCG2POLBKMT2AMEN1LMNA | |
| SCHEMBL3110337 | 0.67 | KMT2A (0.67) | APPPOLBKMT2AMEN1RAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4213987-A | 4-AMINOQUINAZOLINES | SANKYO COMPANY LIMITED (JP) | 1980-07-22 | — | — | US | disclosed |