Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 2/20 | 0.61 |
| ▸ | CCR4 | P51679 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 4/20 | 0.48 |
| ▸ | PDE5A | O76074 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.43 |
| ▸ | ACP1 | P24666 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11255510 | 0.94 | GBA1 (0.55) | GBA1CCR4APPPDE5AMAOA | |
| SCHEMBL11246446 | 0.93 | GBA1 (0.54) | GBA1CCR4APPPDE5AMAOA | |
| SCHEMBL11255273 | 0.85 | APP (0.46) | GBA1CCR4APPPDE5AMEN1 | |
| SCHEMBL11256846 | 0.81 | NR2F2 (0.59) | GBA1CCR4APPMAOAPTGS1 | |
| SCHEMBL11248882 | 0.77 | EGFR (0.52) | GBA1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL18354345 | 0.77 | GBA1 (1.00) | GBA1PDE5APTGS1MEN1KMT2A | |
| SCHEMBL25243367 | 0.75 | MAPT (0.67) | GBA1APPPDE5AMEN1KMT2A | |
| SCHEMBL11255628 | 0.74 | GBA1 (0.56) | GBA1APPMAOAPTGS1NPC1 | |
| SCHEMBL11261278 | 0.74 | EGFR (0.52) | GBA1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL11250201 | 0.74 | APP (0.63) | GBA1APPPDE5AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4323680-A | 4-Aminoquinazoline compounds useful as agricultural fungicides | SANKYO COMPANY LIMITED (JP) | 1982-04-06 | — | — | US | disclosed |
| US-4213987-A | 4-AMINOQUINAZOLINES | SANKYO COMPANY LIMITED (JP) | 1980-07-22 | — | — | US | disclosed |