Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 4/20 | 0.45 |
| ▸ | PDE5A | O76074 | 1/20 | 0.45 |
| ▸ | CCR4 | P51679 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SCN4A | P35499 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11255646 | 0.94 | GBA1 (0.61) | GBA1APPPDE5ACCR4NPC1 | |
| SCHEMBL11246446 | 0.92 | GBA1 (0.54) | GBA1MAPTHTTAPPPDE5A | |
| SCHEMBL11248882 | 0.84 | EGFR (0.52) | GBA1MAPTHTTNPC1RAB9A | |
| SCHEMBL11255273 | 0.79 | APP (0.46) | GBA1MAPTHTTAPPPDE5A | |
| SCHEMBL11246670 | 0.76 | GBA1 (0.55) | GBA1MAPTHTTAPPPDE5A | |
| SCHEMBL11256846 | 0.76 | NR2F2 (0.59) | GBA1MAPTHTTAPPCCR4 | |
| SCHEMBL11254689 | 0.75 | MEN1 (0.59) | GBA1MAPTHTTAPPPDE5A | |
| SCHEMBL11255628 | 0.74 | GBA1 (0.56) | GBA1MAPTHTTAPPNPC1 | |
| SCHEMBL11250025 | 0.72 | NPC1 (0.52) | GBA1MAPTHTTNPC1RAB9A | |
| SCHEMBL25243367 | 0.72 | MAPT (0.67) | GBA1MAPTHTTAPPPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4323680-A | 4-Aminoquinazoline compounds useful as agricultural fungicides | SANKYO COMPANY LIMITED (JP) | 1982-04-06 | — | — | US | disclosed |
| US-4213987-A | 4-AMINOQUINAZOLINES | SANKYO COMPANY LIMITED (JP) | 1980-07-22 | — | — | US | disclosed |