SCHEMBL11486802

SCHEMBL11486802

N#Cc1cc(N)ncc1N

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PIK3CD O00329 1/20 0.42
CSNK1A1 P48729 1/20 0.39
CLK4 Q9HAZ1 1/20 0.39
NOS3 P29474 2/20 0.38
NOS1 P29475 2/20 0.38
NOS2 P35228 2/20 0.38
PIK3CA P42336 1/20 0.38
PDPK1 O15530 1/20 0.35
HTT P42858 1/20 0.35
ALOX5AP P20292 1/20 0.35
FEN1 P39748 1/20 0.35
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
ADORA2A P29274 1/20 0.34
ADORA1 P30542 1/20 0.34
KDR P35968 2/20 0.34
KDM4E B2RXH2 2/20 0.33
KHK P50053 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16668748 0.84 CSNK1A1 (0.45) PIK3CDCSNK1A1CLK4NOS3NOS1
SCHEMBL30971228 0.82 CSNK1A1 (0.44) PIK3CDCSNK1A1CLK4NOS3NOS1
SCHEMBL1457800 0.82 CSNK1A1 (0.44) PIK3CDCSNK1A1CLK4NOS3NOS1
SCHEMBL25778172 0.80 CSNK1A1 (0.38) PIK3CDCSNK1A1CLK4HTTADORA2A
SCHEMBL23908930 0.78 XDH (0.39) PIK3CDCSNK1A1CLK4NOS3NOS1
SCHEMBL20157559 0.78 CSNK1A1 (0.37) PIK3CDCSNK1A1CLK4NOS3NOS1
SCHEMBL30868505 0.78 HTT (0.46) PIK3CDCSNK1A1CLK4NOS3NOS1
SCHEMBL1815383 0.78 XDH (0.40) PIK3CDCSNK1A1CLK4NOS3NOS1
SCHEMBL25234861 0.78 CSNK1A1 (0.46) PIK3CDCSNK1A1CLK4HTTADORA2A
SCHEMBL18031200 0.78 NOS3 (0.56) PIK3CDCSNK1A1CLK4NOS3NOS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4208343-A STARTING MATERIALS FOR CYANO-IMIDE POLYMERS WESTINGHOUSE ELECTRIC CORP. (US) 1980-06-17 US disclosed