Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11493964 | 0.88 | KMT2A (0.45) | HRH3KMT2ATSHRMEN1NPSR1 | |
| SCHEMBL11494214 | 0.86 | HRH3 (0.47) | HRH3KMT2AUSP2TSHRMEN1 | |
| SCHEMBL11489383 | 0.86 | CD274 (0.48) | HRH3KMT2AUSP2ALDH1A1MAPT | |
| SCHEMBL24351544 | 0.74 | SIGMAR1 (0.70) | HRH3KMT2AALDH1A1MAPTSIGMAR1 | |
| SCHEMBL4423135 | 0.73 | POLB (0.58) | HRH3NPSR1ALDH1A1HTR1AMAOA | |
| SCHEMBL6502154 | 0.73 | ALDH1A1 (0.51) | KMT2ATSHRMEN1ALDH1A1MAPT | |
| 4-(4-Chlorobenzyl)Morpholine SCHEMBL4103722 | 0.71 | HRH3 (0.74) | HRH3KMT2AUSP2TSHRMEN1 | |
| SCHEMBL4425761 | 0.71 | CYP2C19 (0.65) | HRH3KMT2AMEN1NPSR1ALDH1A1 | |
| SCHEMBL14046067 | 0.71 | KCNH2 (0.50) | MAOBKCNH2 | |
| SCHEMBL14046066 | 0.69 | MAOB (0.39) | KMT2ATSHRMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4239759-A | Morpholino containing compounds, compositions and use thereof | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1980-12-16 | — | — | US | disclosed |
| US-4110447-A | Anti-inflammatory (halo-4-biphenylyl)-alkanolamines | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1978-08-29 | — | — | US | disclosed |