Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27903062 | 0.83 | ALDH1A1 (0.46) | ALDH1A1KMT2AMAPTHTR1AMAOA | |
| SCHEMBL7408919 | 0.83 | SIGMAR1 (0.53) | ALDH1A1KMT2AMAPTCNR1NPC1 | |
| SCHEMBL11474889 | 0.76 | ALDH1A1 (0.58) | ALDH1A1KMT2AMAPTHTR1AMAOA | |
| SCHEMBL11474887 | 0.76 | ALDH1A1 (0.58) | ALDH1A1KMT2AMAPTHTR1AMAOA | |
| SCHEMBL8636775 | 0.74 | CNR1 (0.55) | ALDH1A1SMN1; SMN2CNR1L3MBTL1SIGMAR1 | |
| SCHEMBL11475244 | 0.74 | KMT2A (0.46) | ALDH1A1KMT2AMAPTHTR1AMAOA | |
| SCHEMBL24351544 | 0.74 | SIGMAR1 (0.70) | ALDH1A1KMT2AMAPTHTR1AMAOA | |
| SCHEMBL11487214 | 0.73 | HRH3 (0.51) | ALDH1A1KMT2AMAPTHTR1AMAOA | |
| SCHEMBL780339 | 0.72 | HSP90AA1 (0.74) | ALDH1A1KMT2AMAPTHTR1AMAOA | |
| SCHEMBL780338 | 0.72 | HSP90AA1 (0.74) | ALDH1A1KMT2AMAPTHTR1AMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6844347-B1 | Cyclic guanosine monophosphate modulators; cardiovascular diseases; guanylate cyclase activation | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2005-01-18 | — | — | US | disclosed |