SCHEMBL11489416

SCHEMBL11489416

CC(O)(CCCN1CCCCC1)c1ccc(-c2ccc(F)cc2)cc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 2/20 0.49
CHRM4 P08173 2/20 0.49
CHRM5 P08912 2/20 0.49
CHRM1 P11229 2/20 0.49
CHRM3 P20309 2/20 0.49
SIGMAR1 Q99720 2/20 0.49
ALDH1A1 P00352 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
KDM4E B2RXH2 1/20 0.49
HTR1A P08908 1/20 0.49
CYP2D6 P10635 1/20 0.49
DRD2 P14416 1/20 0.49
DRD1 P21728 1/20 0.49
HTR2A P28223 1/20 0.49
OPRM1 P35372 1/20 0.49
DRD3 P35462 1/20 0.49
SCN1A P35498 1/20 0.49
KCNH2 Q12809 1/20 0.49
SCN2A Q99250 1/20 0.49
SCN3A Q9NY46 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11496019 0.92 SLC6A4 (0.53) CHRM2CHRM1ALDH1A1SMN1; SMN2HTR1A
SCHEMBL11487540 0.92 SLC6A4 (0.53) CHRM2CHRM1ALDH1A1SMN1; SMN2HTR1A
SCHEMBL11492535 0.90 SLC6A4 (0.54) CHRM2CHRM1ALDH1A1SMN1; SMN2HTR1A
SCHEMBL11492973 0.88 KCNH2 (0.61) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL11496445 0.87 ALDH1A1 (0.55) SIGMAR1ALDH1A1SLC6A4SLC6A3
SCHEMBL11489162 0.86 CHRM2 (0.49) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL11496128 0.86 CHRM2 (0.49) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL11486937 0.83 ALDH1A1 (0.47) ALDH1A1SMN1; SMN2HRH3HTR3A
SCHEMBL8967625 0.81 CHRM2 (0.72) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL11489140 0.81 SLC6A4 (0.56) CHRM2CHRM4CHRM5CHRM1CHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4239759-A Morpholino containing compounds, compositions and use thereof MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1980-12-16 US disclosed
US-4110447-A Anti-inflammatory (halo-4-biphenylyl)-alkanolamines MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) 1978-08-29 US disclosed