Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 6/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11489610 | 0.85 | MEN1 (0.40) | HTR1AHTR7HTR6KDM4ECYP1A2 | |
| SCHEMBL11489088 | 0.85 | MEN1 (0.44) | AKT1ADRB2HTR1AHTR7HTR6 | |
| SCHEMBL11486425 | 0.84 | GRIA4 (0.47) | ADRB2HTR1ACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL11496377 | 0.84 | SLC6A4 (0.45) | AKT1ADRB2UTS2R | |
| SCHEMBL11488179 | 0.83 | HTT (0.40) | ADRB2HTR1AHTR7HTR6 | |
| SCHEMBL11488016 | 0.81 | AKT1 (0.41) | AKT1ADRB2MCHR1KDM4EUTS2R | |
| SCHEMBL11489472 | 0.80 | AKT1 (0.44) | AKT1ADRB2UTS2R | |
| SCHEMBL11494299 | 0.80 | AKT1 (0.50) | AKT1ADRB2UTS2R | |
| SCHEMBL11603164 | 0.80 | AKT1 (0.40) | AKT1ADRB2UTS2R | |
| SCHEMBL11496237 | 0.78 | ADRB2 (0.43) | AKT1ADRB2CYP1A2UTS2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4239759-A | Morpholino containing compounds, compositions and use thereof | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1980-12-16 | — | — | US | disclosed |
| US-4110447-A | Anti-inflammatory (halo-4-biphenylyl)-alkanolamines | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1978-08-29 | — | — | US | disclosed |