Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11489797 | 1.00 | POLB (0.31) | POLBLMNATSHRJAK2HSD17B1 | |
| SCHEMBL11540592 | 0.84 | ALOX15 (0.32) | HSD17B1 | |
| SCHEMBL11540590 | 0.84 | ALOX15 (0.32) | HSD17B1 | |
| SCHEMBL11488209 | 0.84 | LSS (0.40) | POLBKDM4EALDH1A1MAPTAGTR1 | |
| SCHEMBL11488207 | 0.84 | LSS (0.40) | POLBKDM4EALDH1A1MAPTAGTR1 | |
| SCHEMBL11492888 | 0.83 | ALDH1A1 (0.41) | LMNATSHRKDM4EALDH1A1MAPT | |
| SCHEMBL11492883 | 0.83 | ALDH1A1 (0.41) | LMNATSHRKDM4EALDH1A1MAPT | |
| SCHEMBL11489699 | 0.82 | ALOX15 (0.31) | — | |
| SCHEMBL11492616 | 0.78 | MAPK1 (0.41) | LMNATSHRALDH1A1MAPT | |
| SCHEMBL11492612 | 0.78 | MAPK1 (0.41) | LMNATSHRALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4239759-A | Morpholino containing compounds, compositions and use thereof | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1980-12-16 | — | — | US | disclosed |
| US-4110447-A | Anti-inflammatory (halo-4-biphenylyl)-alkanolamines | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1978-08-29 | — | — | US | disclosed |