Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | PLAAT3 | P53816 | 2/20 | 0.48 |
| ▸ | PLAAT5 | Q96KN8 | 2/20 | 0.48 |
| ▸ | PLAAT2 | Q9NWW9 | 2/20 | 0.48 |
| ▸ | PLAAT4 | Q9UL19 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11490144 | 0.88 | HTT (0.56) | HTTNPSR1L3MBTL1USP2HPGD | |
| SCHEMBL11495362 | 0.83 | HTT (0.49) | HTTNPSR1L3MBTL1USP2HPGD | |
| SCHEMBL11490047 | 0.81 | SIGMAR1 (0.42) | HTTMEN1KMT2ASMN1; SMN2HDAC3 | |
| SCHEMBL11490100 | 0.76 | POLB (0.53) | NPSR1HPGDMEN1KMT2AHDAC3 | |
| SCHEMBL11494201 | 0.75 | CNR2 (0.46) | HTTHPGDMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL15845229 | 0.74 | GAA (0.60) | L3MBTL1HPGDTRPV1HDAC3HDAC1 | |
| SCHEMBL13073412 | 0.73 | HDAC3 (0.78) | L3MBTL1HPGDMEN1KMT2APLAAT3 | |
| SCHEMBL207794 | 0.72 | SMN1; SMN2 (0.70) | HTTUSP2HPGDMEN1KMT2A | |
| SCHEMBL19334423 | 0.72 | TSHR (0.67) | HTTUSP2HPGDMEN1KMT2A | |
| SCHEMBL10436247 | 0.72 | HDAC3 (0.74) | L3MBTL1MEN1KMT2APLAAT3PLAAT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4202832-A | ANTILIPEMIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1980-05-13 | — | — | US | disclosed |