Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.49 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11490096 | 0.87 | POLB (0.55) | POLBEPHX2GAAHPGDEPHX1 | |
| SCHEMBL11490047 | 0.81 | SIGMAR1 (0.42) | POLBGAACYP2C9CYP2C19LMNA | |
| SCHEMBL11491368 | 0.78 | HPGD (0.49) | GAAHPGDCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL11490146 | 0.76 | HTT (0.55) | HPGDLMNAHDAC3HDAC1HDAC2 | |
| SCHEMBL11494201 | 0.74 | CNR2 (0.46) | POLBGAAHPGDLMNAHDAC3 | |
| SCHEMBL7568943 | 0.72 | EPHX2 (0.64) | POLBEPHX2HPGDEPHX1HDAC3 | |
| SCHEMBL11495724 | 0.72 | USP2 (0.51) | HPGDLMNAKMT2AMAPT | |
| SCHEMBL23130338 | 0.71 | POLB (1.00) | POLBEPHX2GAAHPGDEPHX1 | |
| SCHEMBL12329225 | 0.70 | EPHX2 (0.57) | POLBEPHX2HPGDEPHX1CYP1A2 | |
| SCHEMBL24011222 | 0.70 | EPHX1 (0.67) | POLBEPHX2HPGDEPHX1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4202832-A | ANTILIPEMIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1980-05-13 | — | — | US | disclosed |