Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL427423 | 0.84 | KCNJ1 (0.55) | ALDH1A1KCNJ1MAPTLMNASMN1; SMN2 | |
| SCHEMBL11486715 | 0.82 | ALDH1A1 (0.62) | ALDH1A1LMNAKMT2AMEN1TP53 | |
| SCHEMBL11495457 | 0.81 | ALDH1A1 (0.60) | ALDH1A1LMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL11486569 | 0.81 | ALDH1A1 (0.63) | ALDH1A1MAPTLMNASMN1; SMN2KMT2A | |
| SCHEMBL11496100 | 0.81 | ALDH1A1 (0.60) | ALDH1A1LMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL11492547 | 0.81 | ALDH1A1 (0.60) | ALDH1A1MAPTLMNASMN1; SMN2KMT2A | |
| Aniline SCHEMBL27545632 | 0.76 | KCNJ1 (0.46) | ALDH1A1KCNJ1MAPTLMNASMN1; SMN2 | |
| SCHEMBL11690787 | 0.75 | HSD11B1 (0.43) | ALDH1A1MAPTLMNATDP1POLB | |
| SCHEMBL11489245 | 0.75 | ALDH1A1 (0.56) | ALDH1A1LMNAKMT2AMEN1POLB | |
| SCHEMBL11496445 | 0.74 | ALDH1A1 (0.55) | ALDH1A1KMT2AMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4239759-A | Morpholino containing compounds, compositions and use thereof | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1980-12-16 | — | — | US | disclosed |
| US-4110447-A | Anti-inflammatory (halo-4-biphenylyl)-alkanolamines | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1978-08-29 | — | — | US | disclosed |