Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11493174 | 0.89 | KCNA3 (0.50) | HRH3ALDH1A1MAOB | |
| SCHEMBL11496037 | 0.89 | GAA (0.49) | SIGMAR1HRH3ALDH1A1 | |
| SCHEMBL11496502 | 0.88 | CYP1A2 (0.47) | SIGMAR1HRH3ALDH1A1 | |
| SCHEMBL11494283 | 0.88 | KDM4E (0.53) | HRH3ALDH1A1MAOB | |
| SCHEMBL11495321 | 0.88 | SLC6A4 (0.50) | HRH3ALDH1A1MAOB | |
| SCHEMBL11487323 | 0.87 | LTA4H (0.56) | HRH3ALDH1A1 | |
| SCHEMBL11486080 | 0.86 | HRH3 (0.56) | HRH3MAOB | |
| SCHEMBL11487560 | 0.86 | HTT (0.55) | ALDH1A1 | |
| SCHEMBL11487622 | 0.86 | LTA4H (0.55) | HRH3ALDH1A1 | |
| SCHEMBL11493999 | 0.85 | ALDH1A1 (0.43) | SIGMAR1HRH3ALDH1A1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4239759-A | Morpholino containing compounds, compositions and use thereof | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1980-12-16 | — | — | US | disclosed |
| US-4110447-A | Anti-inflammatory (halo-4-biphenylyl)-alkanolamines | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1978-08-29 | — | — | US | disclosed |