Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11489914 | 0.86 | GLA (0.53) | ALDH1A1KMT2AKDM4EPABPC1ATM | |
| Hydrochloric Acid SCHEMBL11490843 | 0.83 | GLA (0.50) | ALDH1A1KMT2AKDM4EPABPC1ATM | |
| Bromide SCHEMBL9080240 | 0.75 | KMT2A (0.53) | ALDH1A1KMT2AKDM4EPABPC1MEN1 | |
| SCHEMBL12534300 | 0.73 | KMT2A (0.50) | ALDH1A1KMT2AKDM4EPABPC1MEN1 | |
| Bromide SCHEMBL26128657 | 0.72 | HTT (0.43) | ALDH1A1KMT2AKDM4EPABPC1ATM | |
| Diphenylether SCHEMBL27690785 | 0.72 | HPGD (0.53) | ALDH1A1SMN1; SMN2HPGDCYP1A2CYP2C9 | |
| Hydrochloric Acid SCHEMBL5848674 | 0.71 | HSP90AA1 (0.50) | ALDH1A1KMT2AKDM4EMEN1USP2 | |
| Bromide SCHEMBL11484628 | 0.71 | GLA (0.44) | ALDH1A1KMT2AKDM4EPABPC1ATM | |
| Bromide SCHEMBL22366434 | 0.71 | LTA4H (0.46) | PABPC1BCHEEIF4HCTDSP1 | |
| SCHEMBL26415684 | 0.71 | HTT (0.41) | ALDH1A1KMT2AKDM4EPABPC1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4187311-A | TREATMENT OF SENILITY AND REVERSAL OF AMNESIA | WARNER-LAMBERT COMPANY (US) | 1980-02-05 | — | — | US | claimed |
| US-4187311-A | TREATMENT OF SENILITY AND REVERSAL OF AMNESIA | WARNER-LAMBERT COMPANY (US) | 1980-02-05 | — | — | US | disclosed |