Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 12/20 | 0.56 |
| ▸ | HTR2A | P28223 | 11/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11606085 | 0.80 | FFAR1 (0.39) | SLC6A4HTR2ACYP2D6KMT2A | |
| SCHEMBL11494080 | 0.80 | XIAP (0.43) | SLC6A4HTR2AADRB2ADRB1CYP2D6 | |
| SCHEMBL5836321 | 0.76 | HTR2A (0.61) | SLC6A4HTR2AKCNH2SLC6A2SLC6A3 | |
| SCHEMBL5609057 | 0.74 | HTR2A (0.71) | SLC6A4HTR2AKCNH2SLC6A2SLC6A3 | |
| SCHEMBL5836323 | 0.72 | HTR2A (1.00) | SLC6A4HTR2AKCNH2SLC6A2SLC6A3 | |
| SCHEMBL9226348 | 0.69 | LMNA (0.44) | SLC6A4KCNH2SLC6A2SLC6A3HTT | |
| SCHEMBL11489472 | 0.69 | AKT1 (0.44) | ADRB2HIF1AKMT2A | |
| SCHEMBL20621639 | 0.68 | SLC6A4 (0.44) | SLC6A4HTR2AKCNH2SLC6A2SLC6A3 | |
| SCHEMBL9226204 | 0.67 | MEN1 (0.48) | SLC6A4SLC6A2SLC6A3CYP2D6HTT | |
| SCHEMBL11826285 | 0.67 | HTR2A (0.60) | SLC6A4HTR2AKCNH2SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4239759-A | Morpholino containing compounds, compositions and use thereof | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1980-12-16 | — | — | US | disclosed |