Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | HTT | P42858 | 2/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | HBB | P68871 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | PTGER4 | P35408 | 13/20 | 0.64 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30716977 | 0.92 | ALDH1A1 (0.58) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL20872243 | 0.92 | ALDH1A1 (0.58) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL1149879 | 0.85 | PTGER4 (0.67) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL25132549 | 0.83 | MEN1 (0.62) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL11757062 | 0.83 | KDM4E (0.76) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL20804045 | 0.82 | ALDH1A1 (0.57) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL19896294 | 0.81 | ALDH1A1 (0.44) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL31739343 | 0.80 | ALDH1A1 (0.71) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL10945941 | 0.80 | ALDH1A1 (0.71) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL11752260 | 0.80 | KDM4E (0.66) | MEN1KMT2AKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8207214-B2 | 3-aminocarbazole compounds, pharmaceutical composition containing the same and method for the preparation thereof | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2012-06-26 | — | — | US | disclosed |
| US-20110046197-A1 | 3-AMINOCARBAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AND METHOD FOR THE PREPARATION THEREOF | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCE (IT) | 2011-02-24 | — | — | US | disclosed |
| US-7879900-B2 | Antiinflammatory agents; antitumor agents; Alzheimer's disease;atherosclerosis | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2011-02-01 | — | — | US | disclosed |
| CN-101223139-B | 3-aminocarbazole compound, pharmaceutical composition containing the same, and method for producing the same | ACRAF | 2010-11-17 | — | — | CN | disclosed |
| EP-1910288-B1 | 3-AMINOCARBAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AND METHOD FOR THE PREPARATION THEREOF | ACRAF (IT) | 2010-06-23 | — | — | EP | disclosed |
| US-20080207727-A1 | 3-Aminocarbazole Compounds, Pharmaceutical Composition Containing the Same and Method for the Preparation Thereof | AZIENDE CHIMICHE RIUNTE ANGELINI FRANCE (IT) | 2008-08-28 | — | — | US | disclosed |
| CN-101223139-A | 3-aminocarbazole compound, pharmaceutical composition containing the same, and method for producing the same | ACRAF (IT) | 2008-07-16 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207727-A1 | 3-Aminocarbazole Compounds, Pharmaceutical Composition Containing the Same and Method for the Preparation Thereof | CYP2C19, CYP2C9, CYP3A43 | MEN1 1522/4885KMT2A 2663/4885KDM4E 1007/4885 |
| US-20110046197-A1 | 3-AMINOCARBAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AND METHOD FOR THE PREPARATION THEREOF | IL17A, APC, IL33 | MEN1 2803/4885KMT2A 3794/4885KDM4E 3434/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.