IL33 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL18862291	1.00	2/20
SCHEMBL18862018	0.71	2/20
SCHEMBL18862272	0.55	2/20
SCHEMBL18862278	0.55	2/20
SCHEMBL18862275	0.53	2/20
SCHEMBL28312282	0.53	2/20
SCHEMBL18862279	0.52	2/20
SCHEMBL15315401	0.49	2/20
SCHEMBL15347324	0.48	2/20
SCHEMBL18862269	0.48	2/20
SCHEMBL16316318	0.48	2/20
SCHEMBL10118710	0.47	2/20
SCHEMBL18862021	0.47	2/20
SCHEMBL623595	0.46	2/20
SCHEMBL17589738	0.46	2/20
SCHEMBL626204	0.46	2/20
SCHEMBL18862228	0.46	2/20
SCHEMBL13719371	0.46	2/20
SCHEMBL622199	0.46	2/20
SCHEMBL23507317	0.46	2/20

Clinical trials — most relevant to IL33 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
BenRalizumab Effect on Airway Remodeling in Severe asTHma	PHASE4	UNKNOWN
Anti-viral Effects of Azithromycin in Patients With Asthma and COPD	PHASE4	UNKNOWN
The Effect of Allergen Immunotherapy on Anti-viral Immunity in Patients With Allergic Asthma	PHASE4	COMPLETED
Observation on the Efficacy and Mechanism of SLIT With Dust Mite Allergen for PAR	PHASE2/PHASE3	UNKNOWN
Clinical Response to Rhinovirus Challenge	PHASE2	COMPLETED
Tezepelumab in Allergic Rhinitis and Asthma Study (TEZARS)	PHASE2	ACTIVE_NOT_RECRUITING
Colchicine in Patients With Heart Failure and Preserved Left Ventricular Ejection Fraction	PHASE1/PHASE2	COMPLETED
Serum sST2/ miR-223 as a Dual Biomarker for Disease Activity & Clinical Efficacy of SLIT in HDM-Induced Allergic Rhinitis	PHASE1	COMPLETED
Efficacy of Mepolizumab in Severe Asthmatics on a Long Term (MESILICO)	nan	UNKNOWN
Serum Level of IL-33 in Egyptian Psoriatic Patients	nan	NOT_YET_RECRUITING
Effect of Biologicals on Alternative Functions of Eosinophils in Severe Asthma	nan	ACTIVE_NOT_RECRUITING
Association of Serum Interleukin-33 Levels With Clinical Manifestations in Systemic Lupus Erythematosus	nan	NOT_YET_RECRUITING
Pulmonary Epithelium, Immunology and Development of Asthma: Breathing Together	nan	UNKNOWN
Role of Extracellular Matrix in the Development of Airway Remodeling in Asthma	nan	UNKNOWN
Regulatory T Cell With Related Interleukins in Periodontal Disease Progression	nan	COMPLETED
Evaluation of the Effect of Alpha Lipoic Acid on Radiation Induced Dermatitis in Breast Cancer Patients	nan	RECRUITING
Diagnostic and Translational Values of Point-of-care Blood Eosinophils and Exhaled Nitric Oxide (FeNO) in People Referred by Primary Care for Suspected Asthma	nan	COMPLETED
Kinetics of Nasal Cytokine Responses to Mechanical Stimulation	nan	COMPLETED
Serum Level of IL31,33 and 36 in Egyptian Paients With Psoriasis	nan	UNKNOWN
Blood Lymphocytes in Asthmatics Treated With Therapeutic Proteins	nan	COMPLETED
The Value of Interleukin-1β and Interleukin-33 Genetic Expression in the Pathogenesis and Differentiation of Primary ITP and SLE-Related Thrombocytopenia	nan	NOT_YET_RECRUITING
Asthma Biomarkers for Predicting Response to Therapy	nan	UNKNOWN
Immunological Mechanisms Underlying Mucosal IgE Responses	nan	RECRUITING
Phenotyping Circulating and Lung Resident Eosinophils in Severe Asthma (P-CLESA)	nan	UNKNOWN
The Role Of Neutrophil Proteases As Global Regulators Of Il-1 Family Cytokine Activity In Skin Disorders	nan	UNKNOWN
Study of an Innovative Therapy Using CAR-T Cells Targeting IL-1RAP in Patients With High-Risk Myelodysplastic Syndromes (MDS	nan	NOT_YET_RECRUITING
Interleukin 33 in Juvenile Idiopathic Arthritis Patients	nan	COMPLETED
Allergenic Extract Standardized Cat Hair AP in an Allergic Rhinitis Model.	nan	ACTIVE_NOT_RECRUITING
Using NLP and Neural Networks to Autonomously Identify Severe Asthma and Determine Study Eligibility in a Large Healthcare System	nan	ACTIVE_NOT_RECRUITING
ST-2; a Non-invasive Fibrosis Marker for Chronic Hepatitis B	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a IL33 binder may also engage these)

Protein	Name	Similarity
Q5RDG8	—	1.000	Q5RDG8 →
O97863	—	0.999	O97863 →
Q66H70	—	0.995	Q66H70 →
Q8BVZ5	—	0.994	Q8BVZ5 →
P79340	—	0.994	P79340 →
P48089	—	0.990	P48089 →
P04822	—	0.990	P04822 →
Q28579	—	0.989	Q28579 →
P08831	—	0.989	P08831 →
Q28385	—	0.988	Q28385 →
Q6AX58	—	0.987	Q6AX58 →
P79161	—	0.987	P79161 →
P01582	—	0.987	P01582 →
Q8C0P7	—	0.986	Q8C0P7 →
O46612	—	0.986	O46612 →
O46613	—	0.986	O46613 →
A0A0R4IBK5	—	0.986	A0A0R4IBK5 →
IL1A	Interleukin-1 alpha	0.986	landscape →
Q3HWU1	—	0.986	Q3HWU1 →
Q865X7	—	0.986	Q865X7 →
Q28DE6	—	0.985	Q28DE6 →
Q5DW34	—	0.985	Q5DW34 →
Q8R3P9	—	0.985	Q8R3P9 →
Q1LVQ2	—	0.985	Q1LVQ2 →
Q9D7G4	—	0.985	Q9D7G4 →
O15050	—	0.985	O15050 →
Q6NU22	—	0.985	Q6NU22 →
Q9Z2U2	—	0.985	Q9Z2U2 →
P46647	—	0.985	P46647 →
O88196	—	0.985	O88196 →