Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 9/20 | 0.64 |
| ▸ | ADRB1 | P08588 | 9/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.64 |
| ▸ | HTR1A | P08908 | 2/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.64 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.64 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.64 |
| ▸ | HTR2B | P41595 | 1/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.64 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11507481 | 0.94 | ADRB2 (0.61) | ADRB2ADRB1LMNAADRA1ACYP2D6 | |
| SCHEMBL11506652 | 0.87 | ADRB2 (0.65) | ADRB2ADRB1ADRA1ACYP2D6PMP22 | |
| SCHEMBL11506632 | 0.86 | ADRB2 (0.63) | ADRB2ADRB1ADRA1ACYP2D6PMP22 | |
| SCHEMBL11847324 | 0.85 | ADRB2 (0.64) | ADRB2ADRB1LMNAADRA1ACYP2D6 | |
| SCHEMBL11507196 | 0.81 | ADRB2 (0.66) | ADRB2ADRB1ADRA1ACYP2D6ADRB3 | |
| SCHEMBL2615170 | 0.81 | ADRB2 (0.66) | ADRB2ADRB1ADRA1ACYP2D6ADRB3 | |
| SCHEMBL11506733 | 0.81 | ADRB2 (0.66) | ADRB2ADRB1ADRA1ACYP2D6ADRB3 | |
| SCHEMBL21793229 | 0.79 | ALDH1A1 (0.77) | ADRB2ADRB1LMNAADRA1ACYP2D6 | |
| SCHEMBL30001190 | 0.79 | ALDH1A1 (0.77) | ADRB2ADRB1LMNAADRA1ACYP2D6 | |
| Alprenolol SCHEMBL34636 | 0.78 | ADRB2 (1.00) | ADRB2ADRB1LMNAADRA1ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4145442-A | ADRENERGIC STIMULANTS; ANTAGONIST, ANTAGONISM | AKTIEBOLAGET HASSLE (SE) | 1979-03-20 | — | — | US | disclosed |
| US-3996382-A | Phenoxy-hydroxypropylamines, their preparation, and method and pharmaceutical preparations for treating cardiovascular diseases | AKTIEBOLAGET HASSLE (SW) | 1976-12-07 | — | — | US | disclosed |