Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.86 |
| ▸ | DRD3 | P35462 | 5/20 | 0.86 |
| ▸ | HTR1A | P08908 | 5/20 | 0.86 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.86 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.86 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.86 |
| ▸ | HTR2A | P28223 | 3/20 | 0.86 |
| ▸ | HRH1 | P35367 | 3/20 | 0.86 |
| ▸ | HTR2B | P41595 | 3/20 | 0.86 |
| ▸ | USP2 | O75604 | 2/20 | 0.86 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.86 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.86 |
| ▸ | LMNA | P02545 | 2/20 | 0.86 |
| ▸ | MEN1 | O00255 | 1/20 | 0.86 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.86 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.86 |
| ▸ | GMNN | O75496 | 1/20 | 0.86 |
| ▸ | GLA | P06280 | 1/20 | 0.86 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.86 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.86 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11507943 | 0.93 | DRD2 (0.86) | DRD2DRD3HTR1ASLC6A4OPRM1 | |
| SCHEMBL11509148 | 0.92 | OPRM1 (1.00) | DRD2DRD3HTR1ASLC6A4OPRM1 | |
| Domperidone SCHEMBL29373565 | 0.92 | OPRM1 (1.00) | DRD2DRD3HTR1ASLC6A4OPRM1 | |
| Domperidone SCHEMBL43729 | 0.92 | OPRM1 (1.00) | DRD2DRD3HTR1ASLC6A4OPRM1 | |
| Domperidone SCHEMBL29177488 | 0.92 | OPRM1 (0.98) | DRD2DRD3HTR1ASLC6A4OPRM1 | |
| Domperidone SCHEMBL27988838 | 0.92 | OPRM1 (0.98) | DRD2DRD3HTR1ASLC6A4OPRM1 | |
| Domperidone SCHEMBL5569643 | 0.92 | OPRM1 (0.98) | DRD2DRD3HTR1ASLC6A4OPRM1 | |
| SCHEMBL11506801 | 0.91 | CYP2D6 (0.70) | DRD2DRD3HTR1ASLC6A4OPRM1 | |
| Domperidone SCHEMBL11506647 | 0.91 | OPRM1 (0.96) | DRD2DRD3HTR1ASLC6A4OPRM1 | |
| Water SCHEMBL11508185 | 0.90 | DRD2 (0.94) | DRD2DRD3HTR1ASLC6A4OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4175129-A | Antiemetic 1-(benzoxazolylalkyl)-piperidine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1979-11-20 | — | — | US | disclosed |
| US-4160836-A | Antiemetic 1-(benzothiazolylalkyl)piperidine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1979-07-10 | — | — | US | disclosed |
| US-4126687-A | ANTIEMETIC, 1-(BENZIMIDAZOLYL-ALKYL)-PIPERIDINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1978-11-21 | — | — | US | disclosed |
| US-4126688-A | ANTIEMETIC 1-(BENZOTRIAZOLYL-ALKYL)-PIPERIDINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1978-11-21 | — | — | US | disclosed |
| US-4110333-A | ANTIEMETIC INTERMEDIATES | JANSSEN PHARMACEUTICA N.V. (BE) | 1978-08-29 | — | — | US | disclosed |
| US-4066772-A | ANTIEMETICS | JANSSEN PHARMACEUTICA N.V. (BE) | 1978-01-03 | — | — | US | disclosed |