Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | GPR139 | Q6DWJ6 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.33 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.33 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11509389 | 0.88 | GPR139 (0.38) | RAB9AGPR139LMNASMN1; SMN2KCNJ6 | |
| SCHEMBL11508498 | 0.86 | HPGD (0.40) | RAB9AGPR139LMNAKCNJ6KCNJ5 | |
| SCHEMBL11507688 | 0.85 | GPR139 (0.38) | GPR139LMNAKCNJ6KCNJ5KCNJ3 | |
| SCHEMBL11508518 | 0.85 | GPR139 (0.37) | GPR139KCNJ6KCNJ5KCNJ3MAPT | |
| SCHEMBL11509147 | 0.82 | GPR139 (0.36) | GPR139LMNAKCNJ6KCNJ5KCNJ3 | |
| SCHEMBL11507511 | 0.81 | GPR139 (0.35) | GPR139LMNAKCNJ6KCNJ5KCNJ3 | |
| SCHEMBL11507580 | 0.80 | ALDH1A1 (0.43) | GPR139LMNASMN1; SMN2KCNJ6KCNJ5 | |
| SCHEMBL11510661 | 0.80 | SLC6A3 (0.38) | GPR139LMNASMN1; SMN2KCNJ6KCNJ5 | |
| SCHEMBL11508636 | 0.79 | GPR139 (0.38) | GPR139LMNASMN1; SMN2KCNJ6KCNJ5 | |
| SCHEMBL11507289 | 0.78 | KCNJ6 (0.36) | GPR139LMNASMN1; SMN2KCNJ6KCNJ5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4160098-A | DIURETICS, SALURETICS, HYPOTENSIVE AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1979-07-03 | — | — | US | disclosed |
| US-4122281-A | DIURETIC, SALURETIC, ANTIHYPERTENSIVE | BAYER AKTIENGESELLSCHAFT (DE) | 1978-10-24 | — | — | US | disclosed |
| US-4122280-A | DIURETIC, SALURETIC, ANTIHYPERTENSIVE | BAYER AKTIENGESELLSCHAFT (DE) | 1978-10-24 | — | — | US | disclosed |
| US-4122279-A | DIURETIC, SALURETIC, ANTIHYPERTENSIVE | BAYER AKTIENGESELLSCHAFT (DE) | 1978-10-24 | — | — | US | disclosed |
| US-4096152-A | DIURETICS, SALURETICS, HYPOTENSIVE | BAYER AKTIENGESELLSCHAFT (DT) | 1978-06-20 | — | — | US | disclosed |
| US-4002641-A | DIURETICS, SALURETICS, HYPOTENSIVES | BAYER AKTIENGESELLSCHAFT (DT) | 1977-01-11 | — | — | US | disclosed |