Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 7/20 | 0.54 |
| ▸ | CA12 | O43570 | 5/20 | 0.54 |
| ▸ | CA2 | P00918 | 5/20 | 0.54 |
| ▸ | CA9 | Q16790 | 5/20 | 0.54 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.54 |
| ▸ | CA1 | P00915 | 4/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | CA7 | P43166 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 7/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL64970 | 0.97 | — | — | |
| Hydrochloric Acid SCHEMBL2550273 | 0.94 | ALDH1A1 (0.54) | ALDH1A1HSD17B10ALOX15CA12CA2 | |
| Water SCHEMBL11319775 | 0.94 | ALDH1A1 (0.54) | ALDH1A1HSD17B10ALOX15CA12CA2 | |
| Hydrochloric Acid SCHEMBL31310809 | 0.94 | ALDH1A1 (0.54) | ALDH1A1HSD17B10ALOX15CA12CA2 | |
| SCHEMBL28599140 | 0.87 | ALDH1A1 (0.48) | ALDH1A1HSD17B10ALOX15CA12CA2 | |
| Methoxymethane SCHEMBL9478417 | 0.87 | ALDH1A1 (0.57) | ALDH1A1HSD17B10ALOX15CA12CA2 | |
| SCHEMBL10481889 | 0.85 | ALDH1A1 (0.52) | ALDH1A1HSD17B10ALOX15CA12CA2 | |
| SCHEMBL9763212 | 0.80 | ALDH1A1 (0.69) | ALDH1A1HSD17B10ALOX15CA12CA2 | |
| Ether SCHEMBL9342203 | 0.80 | ALDH1A1 (0.47) | ALDH1A1HSD17B10ALOX15CA12CA2 | |
| 2,4-Diaminophenol SCHEMBL2382912 | 0.77 | ALDH1A1 (0.62) | ALDH1A1HSD17B10ALOX15CA12CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4170452-A | Dye composition containing diphenylamine and polyhydroxybenzene | L'OREAL (FR) | 1979-10-09 | — | — | US | disclosed |