SCHEMBL11515259

SCHEMBL11515259

O=C(O)C(=CNc1ccnc(-c2cccnc2)n1)C(=O)O

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 8/20 0.61
CYP2C19 P33261 6/20 0.57
CYP3A4 P08684 6/20 0.57
CYP2C9 P11712 5/20 0.57
KMT2A Q03164 4/20 0.56
PPARG P37231 1/20 0.56
TDP1 Q9NUW8 1/20 0.56
NR2E3 Q9Y5X4 1/20 0.56
NCOR2 Q9Y618 1/20 0.56
LMNA P02545 2/20 0.55
CYP2D6 P10635 6/20 0.53
CLK4 Q9HAZ1 6/20 0.53
USP2 O75604 1/20 0.53
ALDH1A1 P00352 4/20 0.53
POLB P06746 1/20 0.53
MAPT P10636 1/20 0.53
HTT P42858 1/20 0.53
IDE P14735 1/20 0.52
ALOX15 P16050 2/20 0.51
SMN1; SMN2 Q16637 4/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11517592 0.84 L3MBTL1 (0.53) CYP1A2CYP2C19CYP3A4CYP2C9KMT2A
Hydrochloric Acid SCHEMBL11516685 0.83 L3MBTL1 (0.52) CYP1A2CYP2C19CYP3A4CYP2C9KMT2A
SCHEMBL11514768 0.83 CYP1A2 (0.56) CYP1A2CYP2C19CYP3A4CYP2C9KMT2A
SCHEMBL11513752 0.78 POLB (0.40) CYP1A2CYP2C19CYP3A4CYP2C9KMT2A
SCHEMBL11515274 0.78 ALDH1A1 (0.40) CYP1A2CYP2C19CYP3A4CYP2C9KMT2A
SCHEMBL11515183 0.77 POLB (0.50) CYP1A2CYP2C19CYP3A4CYP2C9KMT2A
SCHEMBL11515601 0.77 POLB (0.41) CYP1A2KMT2AALDH1A1POLBIDE
SCHEMBL11518190 0.76 KDM4E (0.42) KMT2ATDP1ALDH1A1SMN1; SMN2KDM4E
SCHEMBL15966858 0.74 AURKA (0.63) CYP1A2CYP2C19CYP3A4CYP2C9KMT2A
SCHEMBL11515789 0.74 CDC7 (0.38) CYP1A2CYP2C19CYP3A4CYP2C9KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4018770-A ANTIALLERGENS STERLING DRUG INC. (US) 1977-04-19 US claimed
US-RE30024-E ANTIALLERGENS STERLING DRUG INC. (US) 1979-06-05 US disclosed
US-4118571-A ANTIALLERGENS STERLING DRUG INC. (US) 1978-10-03 US disclosed
US-4086233-A ANTIALLERGENS STERLING DRUG INC. (US) 1978-04-25 US disclosed
US-4032523-A ANTIALLERGENS STERLING DRUG INC. (US) 1977-06-28 US disclosed
US-4018770-A ANTIALLERGENS STERLING DRUG INC. (US) 1977-04-19 US disclosed
US-3992380-A 5,8-Dihydro-5-oxo-2-(4-or 3-pyridinyl)pyrido[2,3-d]pyrimidine-6-carboxylic acids and esters STERLING DRUG INC. (US) 1976-11-16 US disclosed