Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 7/20 | 0.46 |
| ▸ | REN | P00797 | 4/20 | 0.46 |
| ▸ | XIAP | P98170 | 1/20 | 0.44 |
| ▸ | PREP | P48147 | 1/20 | 0.44 |
| ▸ | FAP | Q12884 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PEPD | P12955 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11517034 | 0.90 | ACE (0.45) | ACERENXIAPPREPFAP | |
| SCHEMBL18681285 | 0.89 | ACE (0.44) | ACERENXIAPPREPFAP | |
| SCHEMBL11519144 | 0.89 | FKBP5 (0.44) | ACERENXIAPPREPFAP | |
| SCHEMBL11431773 | 0.87 | ACE (0.61) | ACERENKDM4EF2LMNA | |
| SCHEMBL11429475 | 0.87 | KDM4E (0.52) | ACERENPREPFAPKDM4E | |
| SCHEMBL11430017 | 0.86 | KDM4E (0.54) | ACERENKDM4E | |
| SCHEMBL11431101 | 0.86 | KDM4E (0.54) | ACERENKDM4E | |
| SCHEMBL11429463 | 0.86 | KDM4E (0.54) | ACERENKDM4E | |
| SCHEMBL11440574 | 0.84 | PREP (0.61) | ACERENXIAPPREPFAP | |
| SCHEMBL11429550 | 0.84 | NPSR1 (0.52) | ACEREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4176116-A | ELASTASE ENZYME INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1979-11-27 | — | — | US | claimed |
| US-4176116-A | ELASTASE ENZYME INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1979-11-27 | — | — | US | disclosed |