Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.47 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.44 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.39 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM5C | P41229 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4910639 | 0.85 | CYP11B1 (0.59) | CYP11B1CYP11B2ENPP3ENPP1MEN1 | |
| SCHEMBL11679588 | 0.80 | RAB9A (0.46) | MEN1KMT2AMETAP2NPC1RAB9A | |
| SCHEMBL18662151 | 0.80 | SCN10A (0.39) | CYP11B1CYP11B2FYNNPC1RAB9A | |
| SCHEMBL23121272 | 0.80 | FYN (0.47) | MEN1KMT2AMETAP2FYNNPC1 | |
| SCHEMBL5647023 | 0.80 | CYP11B1 (0.47) | CYP11B1CYP11B2ENPP3ENPP1MEN1 | |
| SCHEMBL18850044 | 0.79 | CYP11B1 (0.50) | CYP11B1CYP11B2ENPP3ENPP1MEN1 | |
| SCHEMBL11516493 | 0.79 | CHEK1 (0.46) | CYP11B1CYP11B2MEN1KMT2ANPC1 | |
| SCHEMBL13264053 | 0.78 | MEN1 (0.56) | CYP11B1CYP11B2MEN1KMT2ANPC1 | |
| SCHEMBL4901225 | 0.76 | CYP11B2 (0.49) | CYP11B1CYP11B2ENPP3ENPP1MEN1 | |
| SCHEMBL31301361 | 0.74 | SCN10A (0.51) | CYP11B1CYP11B2SMN1; SMN2SCN2ASCN10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4162319-A | ANTHELMINTICS, PSYCHOTROPIC, CNS, HYPOGLYCOMIC AGENTS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1979-07-24 | — | — | US | disclosed |
| US-4120961-A | ANTIHELMINTICS, CNS ACITVITY | E. MERCK (DE) | 1978-10-17 | — | — | US | disclosed |
| US-4051243-A | RING SUBSTITUTED PYRAZINO-ISOQUINOLINE DERIVATIVES AND THEIR PREPARATION | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) | 1977-09-27 | — | — | US | disclosed |