Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 5/20 | 0.70 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.70 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.70 |
| ▸ | HSP90B1 | P14625 | 4/20 | 0.70 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.70 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.70 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | BLM | P54132 | 2/20 | 0.64 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.64 |
| ▸ | HRH1 | P35367 | 1/20 | 0.64 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.58 |
| ▸ | METTL14 | Q9HCE5 | 1/20 | 0.58 |
| ▸ | AHCY | P23526 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11409631 | 0.98 | ADORA2B (0.70) | ADORA2BADORA3ADORA2AHSP90B1ADORA1 | |
| SCHEMBL11409612 | 0.98 | ADORA2B (0.70) | ADORA2BADORA3ADORA2AHSP90B1ADORA1 | |
| SCHEMBL11416011 | 0.97 | ADORA2B (0.69) | ADORA2BADORA3ADORA2AHSP90B1ADORA1 | |
| SCHEMBL11415994 | 0.97 | ADORA2B (0.69) | ADORA2BADORA3ADORA2AHSP90B1ADORA1 | |
| SCHEMBL9494187 | 0.96 | ADORA2B (0.69) | ADORA2BADORA3ADORA2AHSP90B1ADORA1 | |
| SCHEMBL11408861 | 0.86 | ADORA3 (0.67) | ADORA2BADORA3ADORA2AHSP90B1ADORA1 | |
| SCHEMBL11409857 | 0.85 | ADORA3 (0.70) | ADORA2BADORA3ADORA2AHSP90B1ADORA1 | |
| SCHEMBL9493927 | 0.85 | ADORA3 (0.70) | ADORA2BADORA3ADORA2AHSP90B1ADORA1 | |
| SCHEMBL11703388 | 0.84 | EZH2 (0.65) | ADORA2BADORA3ADORA2AHSP90B1ADORA1 | |
| SCHEMBL11416079 | 0.84 | ADORA2B (0.57) | ADORA2BADORA3ADORA2AHSP90B1ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4167565-A | Adenosine-5'-carboxamides and method of use | ABBOTT LABORATORIES (US) | 1979-09-11 | — | — | US | disclosed |
| US-4029884-A | Adenosine-5'-carboxylic acid amides | ABBOTT LABORATORIES (US) | 1977-06-14 | — | — | US | disclosed |
| US-3966917-A | ADENOSINE-5'-CARBOXAMIDES | ABBOTT LABORATORIES (US) | 1976-06-29 | — | — | US | disclosed |
| US-3931401-A | 1,N6 -etheno-5'-adenosine carboxamides for increasing coronary sinus partial pressure of oxygen | ABBOTT LABORATORIES (US) | 1976-01-06 | — | — | US | disclosed |