Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11518615 | 0.79 | CYP2D6 (0.51) | POLBCYP2D6MEN1CYP1A2CYP3A4 | |
| SCHEMBL11518266 | 0.79 | CYP2D6 (0.56) | POLBCYP2D6MEN1CYP1A2CYP3A4 | |
| SCHEMBL11519908 | 0.78 | FAAH (0.47) | POLBCYP2D6MEN1CYP1A2CYP3A4 | |
| SCHEMBL10846041 | 0.77 | POLB (0.45) | POLBCYP2D6MEN1CYP1A2CYP3A4 | |
| SCHEMBL11517028 | 0.77 | MEN1 (0.59) | POLBCYP2D6MEN1CYP1A2CYP3A4 | |
| SCHEMBL11518878 | 0.75 | CXCR4 (0.46) | POLBCYP2D6MEN1KMT2AADRA2C | |
| SCHEMBL10846038 | 0.74 | MEN1 (0.44) | POLBCYP2D6MEN1CYP1A2CYP3A4 | |
| SCHEMBL10846036 | 0.72 | POLB (0.38) | POLBCYP2D6MEN1CYP1A2CYP3A4 | |
| SCHEMBL11376132 | 0.72 | CYP2D6 (0.40) | POLBCYP2D6MEN1CYP1A2CYP3A4 | |
| SCHEMBL11517203 | 0.72 | CYP2D6 (0.48) | POLBCYP2D6MEN1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4177272-A | HYPOTENSIVE, VASODILATION, PARKINSON'S DISEASE | SCIENCE UNION ET CIE (FR) | 1979-12-04 | — | — | US | disclosed |