SCHEMBL11520191

SCHEMBL11520191

O=P(O)(O)Oc1cc(Cl)cc(Cl)c1

nearest known ligand 0.68

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
INPPL1 O15357 11/20 0.68
INPP5A Q14642 5/20 0.68
SRC P12931 2/20 0.48
INPP5B P32019 1/20 0.48
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
FDPS P14324 1/20 0.39
BLM P54132 1/20 0.38
TSHR P16473 1/20 0.38
AKT1 P31749 1/20 0.38
ALDH1A1 P00352 1/20 0.38
MAPT P10636 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4186085 0.82 INPPL1 (1.00) INPPL1INPP5ASRCINPP5BCA1
SCHEMBL25228996 0.79 INPPL1 (0.65) INPPL1INPP5ASRCINPP5BCA1
SCHEMBL7602618 0.79 SRC (0.58) INPPL1INPP5ASRCINPP5B
SCHEMBL1059938 0.76 MEN1 (0.61) INPPL1INPP5ASRCINPP5BCA1
Hydrochloric Acid SCHEMBL27651690 0.74 MEN1 (0.59) INPPL1INPP5ASRCINPP5BCA1
Water SCHEMBL29937078 0.74 MEN1 (0.59) INPPL1INPP5ASRCINPP5BCA1
SCHEMBL25259132 0.74 INPPL1 (0.48) INPPL1INPP5ASRCINPP5BCA1
SCHEMBL4454764 0.73 INPPL1 (0.71) INPPL1INPP5ASRCINPP5BCA1
Methyl Alcohol SCHEMBL29937073 0.73 MEN1 (0.57) INPPL1INPP5ASRCCA1CA2
SCHEMBL20012157 0.71 INPPL1 (0.76) INPPL1INPP5ASRCINPP5BCA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4144391-A REPLACING AN ACETOXY GROUP BY A SULFUR NUCLEOPHILE ELI LILLY AND COMPANY (US) 1979-03-13 US disclosed