SCHEMBL11524733

SCHEMBL11524733

O=C(O)c1cccc2c1CCc1ccccc1C2=O

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1B1 P15121 2/20 0.56
CES1 P23141 1/20 0.55
ALDH1A1 P00352 5/20 0.53
L3MBTL1 Q9Y468 2/20 0.53
LMNA P02545 2/20 0.49
MAPT P10636 1/20 0.49
GSR P00390 1/20 0.47
TDP1 Q9NUW8 1/20 0.46
SRD5A1 P18405 1/20 0.46
SRD5A2 P31213 1/20 0.46
MAOA P21397 1/20 0.46
MAOB P27338 1/20 0.45
MAPK14 Q16539 2/20 0.45
KDM4E B2RXH2 2/20 0.44
HSP90AA1 P07900 1/20 0.43
HPGD P15428 1/20 0.43
NOTUM Q6P988 1/20 0.43
LIG1 P18858 1/20 0.42
TRPA1 O75762 1/20 0.42
HNF4A P41235 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11524864 0.85 CES1 (0.53) AKR1B1CES1ALDH1A1L3MBTL1MAPT
SCHEMBL11523892 0.85 CES1 (0.53) AKR1B1CES1ALDH1A1L3MBTL1MAPT
SCHEMBL15330692 0.82 ALDH1A1 (0.50) ALDH1A1MAPTKDM4EHSP90AA1HPGD
SCHEMBL29950657 0.82 ALDH1A1 (0.50) ALDH1A1MAPTKDM4EHSP90AA1HPGD
SCHEMBL2770985 0.80 ALDH1A1 (0.46) AKR1B1CES1ALDH1A1L3MBTL1LMNA
SCHEMBL11687006 0.79 MAOB (0.52) ALDH1A1LMNAMAPTMAOAMAOB
SCHEMBL2768852 0.78 TSHR (0.53) AKR1B1CES1ALDH1A1L3MBTL1LMNA
SCHEMBL11001708 0.78 HSP90AA1 (0.51) ALDH1A1L3MBTL1SRD5A1SRD5A2MAOA
SCHEMBL11007908 0.78 HSP90AA1 (0.51) ALDH1A1L3MBTL1MAPTSRD5A1SRD5A2
SCHEMBL44496 0.78 CES1 (0.90) AKR1B1CES1ALDH1A1L3MBTL1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4136116-A ANTIDEPRESSANTS HOFFMANN-LA ROCHE INC. (US) 1979-01-23 US disclosed
US-3952017-A 5-HYDROXY-5-(METHYL OR ALKYLMETHYL-AMINOPROPYL)- 5H-DIBENZO(A,D)CYCLOHEPTENES, ANTIDEPRESSANT HOFFMANN-LA ROCHE INC. (US) 1976-04-20 US disclosed