Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NMT2 | O60551 | 1/20 | 0.31 |
| ▸ | NMT1 | P30419 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26306 | 0.98 | THRB (0.48) | THRBTSHRALDH1A1POLBAPEX1 | |
| Fluoride SCHEMBL8582115 | 0.96 | THRB (0.47) | THRBTSHRALDH1A1POLBAPEX1 | |
| Hydrochloric Acid SCHEMBL1396466 | 0.96 | THRB (0.47) | THRBTSHRALDH1A1POLBAPEX1 | |
| Methacrylic Acid SCHEMBL8170359 | 0.93 | THRB (0.44) | THRBTSHRALDH1A1POLBAPEX1 | |
| SCHEMBL8175481 | 0.93 | ALDH1A1 (0.52) | THRBTSHRALDH1A1POLBAPEX1 | |
| 1,1-Dichloroethene SCHEMBL10925544 | 0.93 | THRB (0.44) | THRBTSHRALDH1A1POLBAPEX1 | |
| Bromide SCHEMBL5250792 | 0.91 | THRB (0.56) | THRBTSHRALDH1A1POLBAPEX1 | |
| SCHEMBL6431278 | 0.91 | THRB (0.47) | THRBTSHRALDH1A1POLBAPEX1 | |
| Acrylic Acid SCHEMBL30601867 | 0.89 | THRB (0.41) | THRBTSHRALDH1A1POLBAPEX1 | |
| SCHEMBL22187021 | 0.89 | TSHR (0.47) | THRBTSHRALDH1A1POLBAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4158726-A | HIGH MOLECULAR WEIGHT, WATER-SOLUBLE CATIONIC ACRYLIC OR METHACRYLIC ESTER POLYMERS | MITSUBISHI CHEMICAL INDUSTRIES LTD. (JP) | 1979-06-19 | — | — | US | disclosed |