Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.39 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11444509 | 0.79 | EPHX1 (0.45) | HTTALDH1A1CYP3A4SMN1; SMN2GAA | |
| SCHEMBL17956791 | 0.79 | ALDH1A1 (0.37) | HTTALDH1A1TP53CYP3A4SMN1; SMN2 | |
| SCHEMBL11529346 | 0.76 | HTT (0.53) | HTTL3MBTL1ALDH1A1TP53CYP3A4 | |
| SCHEMBL9792171 | 0.73 | SIGMAR1 (0.45) | HTTALDH1A1TP53CYP3A4SMN1; SMN2 | |
| SCHEMBL3483261 | 0.72 | HTT (0.47) | HTTL3MBTL1ALDH1A1TP53CYP3A4 | |
| SCHEMBL5452912 | 0.71 | ALDH1A1 (0.51) | HTTL3MBTL1ALDH1A1TP53CYP3A4 | |
| SCHEMBL22400004 | 0.71 | MEN1 (0.53) | HTTL3MBTL1ALDH1A1TP53CYP3A4 | |
| SCHEMBL3483201 | 0.70 | ALDH1A1 (0.46) | HTTL3MBTL1ALDH1A1TP53CYP3A4 | |
| SCHEMBL11439774 | 0.70 | ALDH1A1 (0.58) | HTTL3MBTL1ALDH1A1TP53CYP3A4 | |
| SCHEMBL3482897 | 0.69 | PKM (0.47) | HTTL3MBTL1ALDH1A1TP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4156735-A | SALIDIURETICS | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-05-29 | — | — | US | disclosed |
| US-4118501-A | SALIDIURETIC ACTIVITY | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-10-03 | — | — | US | disclosed |