Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.53 |
| ▸ | CES1 | P23141 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.48 |
| ▸ | RELA | Q04206 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | PPARA | Q07869 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11528029 | 0.90 | SSTR4 (0.48) | CES1RAB9ASMN1; SMN2PKMPPARA | |
| SCHEMBL11528361 | 0.88 | PPARA (0.47) | CES2CES1RAB9ATP53PPARA | |
| SCHEMBL11528571 | 0.86 | SSTR4 (0.47) | CES1SMN1; SMN2ALDH1A1PPARAL3MBTL1 | |
| SCHEMBL11735204 | 0.86 | MRGPRX4 (0.47) | RAB9ASMN1; SMN2TP53MRGPRX4ALDH1A1 | |
| SCHEMBL11530819 | 0.86 | MAP4K4 (0.47) | CES2CES1RAB9ASMN1; SMN2MRGPRX4 | |
| SCHEMBL11532502 | 0.84 | CES2 (0.49) | CES2CES1RAB9ASMN1; SMN2NFKB1 | |
| SCHEMBL11529439 | 0.84 | CES2 (0.49) | CES2CES1RAB9ASMN1; SMN2NFKB1 | |
| SCHEMBL21991543 | 0.82 | PPARA (0.57) | RAB9ASMN1; SMN2ALDH1A1PPARANPC1 | |
| SCHEMBL11735211 | 0.80 | RXRA (0.44) | RAB9APKMMRGPRX4PPARAL3MBTL1 | |
| SCHEMBL757100 | 0.80 | CES1 (0.50) | CES2CES1SMN1; SMN2ALDH1A1PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4065503-A | HYPOLIPIDEMIC AGENTS | SANDOZ, INC. (US) | 1977-12-27 | — | — | US | claimed |
| US-3962459-A | Lipidemia treatment with p-phenoxy-alkylphenone compositions | SANDOZ, INC. (US) | 1976-06-08 | — | — | US | claimed |
| US-4175138-A | α-Alkyl-p-phenoxy benzyl alcohols, compositions and treating lipidemia | SANDOZ, INC. (US) | 1979-11-20 | — | — | US | disclosed |
| US-4085149-A | HYPOLIPIDEMIC | SANDOZ, INC. (US) | 1978-04-18 | — | — | US | disclosed |
| US-4065503-A | HYPOLIPIDEMIC AGENTS | SANDOZ, INC. (US) | 1977-12-27 | — | — | US | disclosed |
| US-3997567-A | HYPOLIPIDEMIC | SANDOZ, INC. (US) | 1976-12-14 | — | — | US | disclosed |
| US-3962459-A | Lipidemia treatment with p-phenoxy-alkylphenone compositions | SANDOZ, INC. (US) | 1976-06-08 | — | — | US | disclosed |
| US-3946119-A | Optionally substituted α-tertiary butyl-p-phenoxybenzylamines and their use as hypolipidemic agents | SANDOZ, INC. (US) | 1976-03-23 | — | — | US | disclosed |