Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.65 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | CNR2 | P34972 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | APEX1 | P27695 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11527568 | 0.99 | TDP1 (0.68) | TDP1KMT2AMEN1NPBWR1MCHR1 | |
| SCHEMBL11353367 | 0.84 | TDP1 (0.71) | TDP1KMT2AMEN1NPBWR1MCHR1 | |
| SCHEMBL5510039 | 0.83 | TDP1 (0.69) | TDP1KMT2AMEN1NPBWR1MCHR1 | |
| SCHEMBL11711932 | 0.82 | TDP1 (1.00) | TDP1KMT2AMEN1NPBWR1MCHR1 | |
| SCHEMBL4715327 | 0.81 | TDP1 (0.97) | TDP1KMT2AMEN1NPBWR1MCHR1 | |
| SCHEMBL4717650 | 0.81 | TDP1 (0.97) | TDP1KMT2AMEN1NPBWR1MCHR1 | |
| SCHEMBL11351226 | 0.80 | ALDH1A1 (0.69) | TDP1KMT2AMEN1NPBWR1MCHR1 | |
| SCHEMBL11172255 | 0.79 | GSK3B (0.50) | TDP1KMT2AMEN1TSHR | |
| SCHEMBL11634436 | 0.79 | MEN1 (0.50) | TDP1KMT2AMEN1NPBWR1MCHR1 | |
| SCHEMBL23677284 | 0.79 | LMNA (0.71) | TDP1KMT2AMEN1NPBWR1MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4156735-A | SALIDIURETICS | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-05-29 | — | — | US | disclosed |
| US-4118501-A | SALIDIURETIC ACTIVITY | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-10-03 | — | — | US | disclosed |