SCHEMBL11533232

SCHEMBL11533232

OC(c1ccccc1)(c1ccc(C(F)(F)F)cc1)c1ncc[nH]1

nearest known ligand 0.62

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 3/20 0.62
ALDH1A1 P00352 1/20 0.44
TSHR P16473 1/20 0.44
AHR P35869 1/20 0.43
CYP3A4 P08684 4/20 0.40
CYP3A5 P20815 3/20 0.40
KIF11 P52732 1/20 0.39
TRPV6 Q9H1D0 1/20 0.38
CYP2D6 P10635 1/20 0.38
SCN2A Q99250 2/20 0.37
MAPT P10636 1/20 0.37
FPR2 P25090 1/20 0.36
CFTR P13569 1/20 0.36
GOPC Q9HD26 1/20 0.36
KMT2A Q03164 1/20 0.36
MTOR P42345 1/20 0.36
ADK P55263 1/20 0.36
NISCH Q9Y2I1 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL11532663 0.92 CYP19A1 (0.68) CYP19A1AHRCYP3A4CYP3A5KIF11
SCHEMBL11536872 0.90 CYP19A1 (0.54) CYP19A1ALDH1A1TSHRAHRCYP3A4
SCHEMBL11537316 0.88 CYP19A1 (0.62) CYP19A1CFTRGOPCKMT2AMTOR
SCHEMBL6090949 0.87 CYP19A1 (0.64) CYP19A1TSHRCYP3A4CFTRGOPC
SCHEMBL11535325 0.84 CYP19A1 (0.62) CYP19A1KIF11CYP2D6SCN2AFPR2
SCHEMBL11532100 0.84 CYP19A1 (0.62) CYP19A1ALDH1A1TSHRCYP3A4KIF11
SCHEMBL11534840 0.84 CYP19A1 (0.88) CYP19A1CYP3A4CYP3A5
SCHEMBL11535106 0.80 CYP19A1 (0.70) CYP19A1CYP3A4
SCHEMBL11533065 0.78 CYP19A1 (0.66) CYP19A1KIF11
SCHEMBL697452 0.78 CYP19A1 (0.49) CYP19A1AHRKIF11TRPV6FPR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4152441-A Analgesic imidazolemethanols GIST-BROCADES N.V. (NL) 1979-05-01 US claimed
US-4152441-A Analgesic imidazolemethanols GIST-BROCADES N.V. (NL) 1979-05-01 US disclosed