Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 4/20 | 0.64 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | ADK | P55263 | 1/20 | 0.42 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11537316 | 0.87 | CYP19A1 (0.62) | CYP19A1MTORADKNISCHKMT2A | |
| SCHEMBL11535325 | 0.87 | CYP19A1 (0.62) | CYP19A1MTORADKNISCHKMT2A | |
| SCHEMBL11532100 | 0.87 | CYP19A1 (0.62) | CYP19A1MTORADKNISCHKMT2A | |
| SCHEMBL11534840 | 0.87 | CYP19A1 (0.88) | CYP19A1CYP3A4 | |
| SCHEMBL11533232 | 0.87 | CYP19A1 (0.62) | CYP19A1MTORADKNISCHKMT2A | |
| SCHEMBL11533069 | 0.84 | CYP19A1 (0.59) | CYP19A1MTORADKNISCHKMT2A | |
| SCHEMBL11535538 | 0.84 | CYP19A1 (0.51) | CYP19A1MTORADKNISCHKMT2A | |
| SCHEMBL11533065 | 0.83 | CYP19A1 (0.66) | CYP19A1TAAR1 | |
| SCHEMBL11536872 | 0.83 | CYP19A1 (0.54) | CYP19A1KMT2ATAAR1CYP3A4TSHR | |
| SCHEMBL17263156 | 0.82 | CYP19A1 (0.49) | CYP19A1MTORADKNISCHKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060211759-A1 | Bis-heterocyclic compounds with antitumour and chemosensitising activity | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2006-09-21 | — | — | US | disclosed |
| EP-1337511-A1 | BIS-HETEROCYCLIC COMPOUNDS WITH ANTITUMOUR AND CHEMOSENSITISING ACTIVITY | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 2003-08-27 | — | — | EP | disclosed |
| WO-2002036561-A1 | BIS-HETEROCYCLIC COMPOUNDS WITH ANTITUMOUR AND CHEMOSENSITISING ACTIVITY | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2002-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211759-A1 | Bis-heterocyclic compounds with antitumour and chemosensitising activity | ABCC1, MCL1, DPYD | CYP19A1 1156/4885MTOR 2203/4885ADK 3366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.