Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 3/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.52 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | MERTK | Q12866 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.39 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5556900 | 0.82 | L3MBTL1 (0.62) | VCAM1L3MBTL1KCNMA1ALDH1A1NPSR1 | |
| SCHEMBL11529474 | 0.81 | HTT (0.41) | VCAM1L3MBTL1ALDH1A1MAPTMERTK | |
| SCHEMBL4836510 | 0.80 | VCAM1 (0.57) | VCAM1L3MBTL1KCNMA1ALDH1A1NPSR1 | |
| SCHEMBL4836315 | 0.79 | VCAM1 (0.56) | VCAM1L3MBTL1KCNMA1ALDH1A1NPSR1 | |
| SCHEMBL11531765 | 0.77 | CYP2A6 (0.39) | ALDH1A1MAPTTDP1HTTSMN1; SMN2 | |
| SCHEMBL4840395 | 0.77 | VCAM1 (0.53) | VCAM1L3MBTL1KCNMA1ALDH1A1NPSR1 | |
| SCHEMBL4844309 | 0.77 | VCAM1 (0.53) | VCAM1L3MBTL1KCNMA1ALDH1A1NPSR1 | |
| SCHEMBL4846304 | 0.77 | EPAS1 (0.55) | VCAM1L3MBTL1ALDH1A1MAPTHTT | |
| SCHEMBL7263524 | 0.76 | VCAM1 (0.52) | VCAM1L3MBTL1KCNMA1ALDH1A1NPSR1 | |
| SCHEMBL1343562 | 0.74 | VCAM1 (1.00) | VCAM1L3MBTL1ALDH1A1MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4172831-A | CENTRAL NERVOUS SYSTEM | LILLY INDUSTRIES LIMITED (GB) | 1979-10-30 | — | — | US | disclosed |
| US-4115574-A | CNS ACTIVITY | LILLY INDUSTRIES LIMITED (GB) | 1978-09-19 | — | — | US | disclosed |
| US-4115568-A | CNS ACTIVITY | LILLY INDUSTRIES LIMITED (GB) | 1978-09-19 | — | — | US | disclosed |