Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
| ▸ | GRM6 | O15303 | 1/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.34 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.34 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11533717 | 0.81 | VCAM1 (0.57) | HTTLMNATRPV1KMT2AMEN1 | |
| SCHEMBL11531797 | 0.77 | LMNA (0.39) | HTTLMNATRPV1KMT2AMEN1 | |
| SCHEMBL11532520 | 0.74 | TRPV1 (0.37) | HTTLMNATRPV1KMT2AMEN1 | |
| SCHEMBL9433775 | 0.73 | VCAM1 (0.46) | HTTTRPV1KMT2AMEN1MAPT | |
| SCHEMBL11629997 | 0.67 | MAPT (0.61) | HTTLMNATRPV1KMT2AMEN1 | |
| SCHEMBL27864501 | 0.64 | MAPT (0.64) | HTTLMNAKMT2AMEN1L3MBTL1 | |
| SCHEMBL4836510 | 0.64 | VCAM1 (0.57) | HTTLMNAL3MBTL1MAPTALDH1A1 | |
| SCHEMBL4841127 | 0.64 | MAPK1 (0.44) | HTTLMNAKMT2AMEN1L3MBTL1 | |
| SCHEMBL11039924 | 0.64 | TSHR (0.56) | HTTLMNAKMT2AMEN1MAPT | |
| SCHEMBL5556900 | 0.63 | L3MBTL1 (0.62) | HTTLMNAL3MBTL1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4172831-A | CENTRAL NERVOUS SYSTEM | LILLY INDUSTRIES LIMITED (GB) | 1979-10-30 | — | — | US | disclosed |
| US-4115574-A | CNS ACTIVITY | LILLY INDUSTRIES LIMITED (GB) | 1978-09-19 | — | — | US | disclosed |
| US-4115568-A | CNS ACTIVITY | LILLY INDUSTRIES LIMITED (GB) | 1978-09-19 | — | — | US | disclosed |