Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 8/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.55 |
| ▸ | THRB | P10828 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 2/20 | 0.55 |
| ▸ | HTR1D | P28221 | 1/20 | 0.52 |
| ▸ | HTR1B | P28222 | 1/20 | 0.52 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD1 | P21728 | 1/20 | 0.50 |
| ▸ | DRD5 | P21918 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4553103 | 0.84 | HSD17B10 (0.57) | LMNAHSD17B10CYP1A2CYP2D6ALOX15 | |
| SCHEMBL4279959 | 0.83 | LMNA (0.67) | LMNAHSD17B10CYP1A2CYP2D6ALOX15 | |
| SCHEMBL4286367 | 0.83 | LMNA (0.67) | LMNAHSD17B10CYP1A2CYP2D6ALOX15 | |
| Calcium SCHEMBL29917796 | 0.82 | LMNA (0.65) | LMNAHSD17B10CYP1A2CYP2D6ALOX15 | |
| SCHEMBL11533335 | 0.80 | MAPT (0.68) | LMNAHSD17B10USP2BAZ2BMAPT | |
| SCHEMBL11530996 | 0.76 | KDM4E (0.54) | HSD17B10CYP1A2CYP2D6PMP22CYP2C9 | |
| SCHEMBL11530731 | 0.76 | LMNA (0.58) | LMNAHSD17B10CYP1A2CYP2D6ALOX15 | |
| SCHEMBL12284690 | 0.76 | HSD17B10 (0.63) | LMNAHSD17B10CYP1A2CYP2D6ALOX15 | |
| SCHEMBL2970063 | 0.75 | HSD17B10 (0.81) | LMNAHSD17B10CYP1A2CYP2D6ALOX15 | |
| SCHEMBL12868547 | 0.74 | HSD17B10 (0.58) | LMNAHSD17B10CYP1A2CYP2D6ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4144349-A | N,N-dimethyl-1,2,4,5,6,7-hexahydrothiocino[5,4-b]-indole-7-propanamine-3,3-dioxides and related thiocines | WARNER-LAMBERT COMPANY (US) | 1979-03-13 | — | — | US | claimed |
| US-4144349-A | N,N-dimethyl-1,2,4,5,6,7-hexahydrothiocino[5,4-b]-indole-7-propanamine-3,3-dioxides and related thiocines | WARNER-LAMBERT COMPANY (US) | 1979-03-13 | — | — | US | disclosed |