Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nilutamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR known ✓ | P10275 | 11/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.73 |
| ▸ | LMNA | P02545 | 2/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.73 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.73 |
| ▸ | TSHR | P16473 | 2/20 | 0.73 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.73 |
| ▸ | PGR | P06401 | 2/20 | 0.73 |
| ▸ | MEN1 | O00255 | 1/20 | 0.73 |
| ▸ | TP53 | P04637 | 1/20 | 0.73 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.73 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.73 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.73 |
| ▸ | RAB9A | P51151 | 1/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.73 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.73 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.73 |
| ▸ | CES2 | O00748 | 1/20 | 0.67 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nilutamide SCHEMBL12670 | 0.85 | AR (1.00) | ARCYP3A4LMNACYP1A2CYP2C9 | |
| Nilutamide SCHEMBL29351021 | 0.85 | AR (1.00) | ARCYP3A4LMNACYP1A2CYP2C9 | |
| Nilutamide SCHEMBL1462011 | 0.85 | AR (1.00) | ARCYP3A4LMNACYP1A2CYP2C9 | |
| Nilutamide SCHEMBL20695037 | 0.84 | AR (0.89) | ARCYP3A4LMNACYP1A2CYP2C9 | |
| Nilutamide SCHEMBL28562851 | 0.84 | AR (0.98) | ARCYP3A4LMNACYP1A2CYP2C9 | |
| Nilutamide SCHEMBL5579273 | 0.82 | AR (0.89) | ARCYP3A4LMNACYP1A2CYP2C9 | |
| Flutamide SCHEMBL29349783 | 0.82 | AR (1.00) | ARCYP3A4LMNACYP1A2CYP2C9 | |
| Flutamide SCHEMBL3934 | 0.82 | AR (1.00) | ARCYP3A4LMNACYP1A2CYP2C9 | |
| Flutamide SCHEMBL1461845 | 0.82 | AR (1.00) | ARCYP3A4LMNACYP1A2CYP2C9 | |
| Bicalutamide SCHEMBL15110318 | 0.81 | AR (0.60) | ARCYP2C19PGRABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110062767-A | Human antibody, pharmaceutical composition and method | 台湾浩鼎生技股份有限公司 | 2019-07-26 | — | — | CN | claimed |
| CN-110062767-A | Human antibody, pharmaceutical composition and method | 台湾浩鼎生技股份有限公司 | 2019-07-26 | — | — | CN | disclosed |
| CN-103717597-B | Heterocyclic compounds as kinase inhibitors | 原真股份有限公司 | 2017-07-04 | — | — | CN | disclosed |
| CN-103492389-B | Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases | 原真股份有限公司 | 2016-09-14 | — | — | CN | disclosed |
| EP-2424853-A2 | NON-STEROIDAL COMPOUNDS FOR ANDROGEN RECEPTOR MODULATION, PROCESSES FOR THE PREPARATION AND USES THEREOF | Consiglio Nazionale Delle Ricerche (IT) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010116342-A2 | NON-STEROIDAL COMPOUNDS FOR ANDROGEN RECEPTOR MODULATION | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 2010-10-14 | — | — | WO | disclosed |