Sugi Predict

Sugi Predict / Compounds / Nilutamide

Nilutamide

Nilutamide

SCHEMBL5579273

CC1(C)NC(=O)N(c2ccc([N+](=O)[O-])c(C(F)(F)F)c2)C1=O.CCO

nearest known ligand 0.89

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

AR

The experimentally established mechanism targets of Nilutamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ AR known ✓ P10275 17/20 0.89
▸ MEN1 O00255 2/20 0.89
▸ LMNA P02545 2/20 0.89
▸ KMT2A Q03164 2/20 0.89
▸ NPSR1 Q6W5P4 2/20 0.89
▸ TP53 P04637 1/20 0.89
▸ CYP1A2 P05177 1/20 0.89
▸ PGR P06401 1/20 0.89
▸ CYP3A4 P08684 1/20 0.89
▸ CYP2D6 P10635 1/20 0.89
▸ CYP2C9 P11712 1/20 0.89
▸ TSHR P16473 1/20 0.89
▸ ALOX12 P18054 1/20 0.89
▸ NFKB1 P19838 1/20 0.89
▸ CYP2C19 P33261 1/20 0.89
▸ RAB9A P51151 1/20 0.89
▸ PDE4D Q08499 1/20 0.89
▸ SMN1; SMN2 Q16637 1/20 0.89
▸ SIRT6 Q8N6T7 1/20 0.47
▸ MAPT P10636 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nilutamide SCHEMBL29351021 0.94 AR (1.00) ARMEN1LMNAKMT2ANPSR1
Nilutamide SCHEMBL12670 0.94 AR (1.00) ARMEN1LMNAKMT2ANPSR1
Nilutamide SCHEMBL1462011 0.94 AR (1.00) ARMEN1LMNAKMT2ANPSR1
Nilutamide SCHEMBL28562851 0.93 AR (0.98) ARMEN1LMNAKMT2ANPSR1
Nilutamide SCHEMBL20695037 0.91 AR (0.89) ARMEN1LMNAKMT2ANPSR1
SCHEMBL332412 0.87 AR (0.73) ARMEN1LMNAKMT2ANPSR1
SCHEMBL10554082 0.87 AR (0.73) ARMEN1LMNAKMT2ANPSR1
SCHEMBL10554935 0.87 AR (0.73) ARMEN1LMNAKMT2ANPSR1
SCHEMBL10324758 0.85 AR (0.81) ARMEN1LMNAKMT2ANPSR1
SCHEMBL8407306 0.83 AR (0.78) ARMEN1LMNAKMT2ANPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070275911-A1 Targeted Drug-Formaldehyde Conjugates and Methods of Making and Using the Same THE REGENTS OF THE UNIVERSITY OF COLORADO 2007-11-29 — — US disclosed
WO-2005034856-A2 TARGETED DRUG-FORMALDEHYDE CONJUGATES AND METHODS OF MAKING AND USING THE SAME THE REGENTS OF THE UNIVERSITY OF COLORADO (US) 2005-04-21 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070275911-A1 Targeted Drug-Formaldehyde Conjugates and Methods of Making and Using the Same HCAR1, DHFR, FOLR1 AR 1530/4885MEN1 3251/4885LMNA 2845/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.