Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.38 |
| ▸ | CHKA known ✓ | P35790 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.34 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11534508 | 0.89 | IDO1 (0.40) | ACHEIDO1 | |
| Water SCHEMBL11535529 | 0.79 | KDR (0.41) | IDO1 | |
| Hydrochloric Acid SCHEMBL11533895 | 0.79 | IDO1 (0.36) | IDO1DNM1 | |
| Water SCHEMBL11536575 | 0.78 | IDO1 (0.35) | IDO1DNM1 | |
| Bromide SCHEMBL11536021 | 0.63 | LMNA (0.39) | ACHECHKA | |
| Bromide SCHEMBL2216768 | 0.61 | CYP19A1 (0.62) | — | |
| SCHEMBL30616069 | 0.60 | CYP19A1 (0.73) | IDO1DNM1 | |
| SCHEMBL29093702 | 0.60 | CYP19A1 (0.73) | IDO1DNM1 | |
| Bromide SCHEMBL11534115 | 0.59 | CNR2 (0.39) | — | |
| SCHEMBL29459650 | 0.59 | HTR6 (0.72) | BIRC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4163745-A | ANTIDIABETIC, HYPOGLYCEMIC | PFIZER INC. (US) | 1979-08-07 | — | — | US | disclosed |
| US-4141898-A | Imidazo pyridinium quaternary salts as hypoglycemic agents | PFIZER INC. (US) | 1979-02-27 | — | — | US | disclosed |
| US-4129567-A | IMIDAZOPYRIDINES AND ISOB IDINE | PFIZER INC. (US) | 1978-12-12 | — | — | US | disclosed |
| US-4093616-A | PYRROLO(1,2-A)PYRAZINIUM, PYRAZOLO(1,5-A)PYRIDINIUM, 1H-IMIDAZO(2,1-A)ISOQUINOLINIUM, OR IMIDAZO(5,1-A)ISOQUINOLINIUM SALTS | PFIZER INC. (US) | 1978-06-06 | — | — | US | disclosed |
| US-4044015-A | Imidazopyridinium compounds as hypoglycemic agents | PFIZER INC. (US) | 1977-08-23 | — | — | US | disclosed |