Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TYR | P14679 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10911325 | 0.86 | L3MBTL1 (0.52) | L3MBTL1KMT2AALDH1A1TP53TYR | |
| SCHEMBL11083418 | 0.81 | L3MBTL1 (0.46) | L3MBTL1KMT2AALDH1A1TP53TYR | |
| SCHEMBL5450263 | 0.77 | GAA (0.46) | L3MBTL1KMT2AALDH1A1TP53TYR | |
| SCHEMBL11882025 | 0.77 | L3MBTL1 (0.41) | L3MBTL1KMT2AGAAKDM4EMEN1 | |
| SCHEMBL8436453 | 0.77 | L3MBTL1 (0.71) | L3MBTL1KMT2AALDH1A1TP53TYR | |
| SCHEMBL13846512 | 0.76 | GAA (0.44) | L3MBTL1KMT2AALDH1A1TP53TYR | |
| SCHEMBL31022673 | 0.76 | L3MBTL1 (1.00) | L3MBTL1KMT2AALDH1A1TP53TYR | |
| SCHEMBL2357864 | 0.76 | L3MBTL1 (1.00) | L3MBTL1KMT2AALDH1A1TP53TYR | |
| SCHEMBL30356255 | 0.74 | KMT2A (0.55) | L3MBTL1KMT2AALDH1A1TP53TYR | |
| SCHEMBL30356290 | 0.74 | KMT2A (0.50) | L3MBTL1KMT2AALDH1A1TP53TYR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110590785-B | Aminothiazole compound, preparation method thereof and application of aminothiazole compound in resisting enterovirus 71 | 武汉大学 | 2021-02-02 | — | — | CN | disclosed |
| CN-110590785-A | Aminothiazole compound, preparation method thereof and application of aminothiazole compound in resisting enterovirus 71 | 武汉大学 | 2019-12-20 | — | — | CN | disclosed |
| US-4169154-A | Method of treating depression with thiourea derivatives | HOFFMANN-LA ROCHE INC. (US) | 1979-09-25 | — | — | US | disclosed |
| US-4150138-A | Method of reducing blood pressure with thiourea derivatives and guanidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 1979-04-17 | — | — | US | disclosed |
| US-4113776-A | HYPOTENSIVE AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1978-09-12 | — | — | US | disclosed |
| US-4096276-A | Thiourea derivatives for treating hypertension | HOFFMANN-LA ROCHE INC. (US) | 1978-06-20 | — | — | US | disclosed |
| US-4066695-A | ANTIHYPERTENSIVE AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1978-01-03 | — | — | US | disclosed |