Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TYR | P14679 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5450263 | 0.84 | GAA (0.46) | GAAL3MBTL1MAPTKMT2APLK1 | |
| SCHEMBL1192648 | 0.81 | GAA (0.67) | GAAL3MBTL1MAPTKMT2APLK1 | |
| SCHEMBL2912546 | 0.76 | KMT2A (0.48) | GAAL3MBTL1MAPTKMT2APLK1 | |
| SCHEMBL11534703 | 0.76 | L3MBTL1 (0.61) | GAAL3MBTL1MAPTKMT2AALDH1A1 | |
| SCHEMBL14415150 | 0.72 | ALDH1A1 (0.44) | GAAL3MBTL1MAPTALDH1A1CYP1A2 | |
| SCHEMBL31389883 | 0.69 | KMT2A (0.41) | GAAL3MBTL1MAPTKMT2AALDH1A1 | |
| SCHEMBL21055027 | 0.69 | ALOX12 (0.42) | L3MBTL1MAPTKMT2AALDH1A1TSHR | |
| SCHEMBL11918917 | 0.68 | ALDH1A1 (0.56) | L3MBTL1MAPTKMT2AALDH1A1CYP1A2 | |
| SCHEMBL10911325 | 0.64 | L3MBTL1 (0.52) | GAAL3MBTL1MAPTKMT2AALDH1A1 | |
| SCHEMBL219165 | 0.64 | ALDH1A1 (0.48) | GAAL3MBTL1MAPTKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067618-A1 | SUBSTITUTED BENZOAZOLE PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |
| WO-2009067604-A1 | SUBSTITUTED BENZOAZOLE PDE4 INHIBITORS FOR TREATING INFLAMMATORY, CARDIOVASCULAR AND CNS DISORDERS | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |