Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP7 | Q9UHL4 | 6/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 5/20 | 0.41 |
| ▸ | DPP4 | P27487 | 2/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.37 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.37 |
| ▸ | CTRB1 | P17538 | 5/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.33 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.33 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.33 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.33 |
| ▸ | GSR | P00390 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18132889 | 0.84 | DPP7 (0.44) | DPP7DPP8DPP4DPP9SLC15A1 | |
| Bromide SCHEMBL11534511 | 0.84 | DPP7 (0.39) | DPP7DPP8DPP4SLC15A1CTRB1 | |
| SCHEMBL19882987 | 0.82 | DPP4 (0.48) | DPP7DPP8DPP4DPP9SLC15A1 | |
| SCHEMBL11532872 | 0.79 | PLA2G2C (0.39) | DPP7DPP8DPP4DPP9GSR | |
| SCHEMBL11538163 | 0.75 | CPB2 (0.33) | DPP7DPP8DPP4DPP9GSR | |
| SCHEMBL11192511 | 0.74 | DPP4 (0.41) | DPP7DPP8DPP4DPP9SLC15A1 | |
| SCHEMBL29674589 | 0.72 | NOD1 (0.56) | DPP7DPP8DPP4NOD1GSR | |
| SCHEMBL27793444 | 0.72 | NOD1 (0.56) | DPP7DPP8DPP4NOD1GSR | |
| SCHEMBL29406243 | 0.72 | NOD1 (0.56) | DPP7DPP8DPP4NOD1GSR | |
| SCHEMBL27793445 | 0.72 | NOD1 (0.56) | DPP7DPP8DPP4NOD1GSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4134918-A | ENZYME INHIBITORS, ANTIBODY INHIBITORS | MERRELL TORAUDE ET COMPAGNIE (FR) | 1979-01-16 | — | — | US | disclosed |