Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 4/20 | 0.48 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | CTRB1 | P17538 | 5/20 | 0.40 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.37 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.32 |
| ▸ | FAP | Q12884 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | XIAP | P98170 | 1/20 | 0.30 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11192511 | 0.86 | DPP4 (0.41) | DPP4DPP8DPP7PAX8CTRB1 | |
| Bromide SCHEMBL11534772 | 0.82 | DPP7 (0.41) | DPP4DPP8DPP7PAX8CTRB1 | |
| SCHEMBL19883041 | 0.81 | CNR2 (0.34) | — | |
| SCHEMBL8271012 | 0.79 | SLC7A5 (0.47) | DPP4DPP8DPP7DPP9 | |
| Bromide SCHEMBL11534511 | 0.79 | DPP7 (0.39) | DPP4DPP8DPP7PAX8CTRB1 | |
| Bromide SCHEMBL11303866 | 0.75 | NOD1 (0.44) | DPP4DPP8DPP7PAX8CTRB1 | |
| SCHEMBL14391478 | 0.74 | PAX8 (0.46) | DPP4DPP8DPP7PAX8CTRB1 | |
| SCHEMBL13187499 | 0.72 | DPP8 (0.50) | DPP4DPP8DPP7PAX8SLC15A1 | |
| SCHEMBL10829688 | 0.72 | — | — | |
| SCHEMBL6010131 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3013805-B1 | SULFOXIMINE SUBSTITUTED QUINAZOLINES AND THEIR USE AS MNK1 AND/OR MNK2 KINASE INHIBITORS | EVOTEC INT GMBH (DE) | 2018-02-21 | — | — | EP | disclosed |