Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 5/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.35 |
| ▸ | AKT2 | P31751 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8329089 | 0.78 | OPRM1 (0.55) | OPRM1DRD3TACR1HTR2AOPRD1 | |
| Hydrochloric Acid SCHEMBL18424795 | 0.77 | OPRM1 (0.54) | OPRM1DRD3TACR1HTR2AOPRD1 | |
| SCHEMBL7512230 | 0.75 | OPRM1 (0.47) | OPRM1DRD3TACR1HTR2AOPRD1 | |
| SCHEMBL3018551 | 0.75 | OPRM1 (0.57) | OPRM1DRD3TACR1HTR2AOPRD1 | |
| SCHEMBL26478588 | 0.75 | OPRM1 (0.41) | OPRM1DRD3TACR1OPRD1OPRK1 | |
| SCHEMBL26413331 | 0.75 | OPRM1 (0.39) | OPRM1TACR1HTR2AOPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL6543335 | 0.74 | OPRM1 (0.46) | OPRM1DRD3TACR1HTR2AOPRD1 | |
| SCHEMBL11536155 | 0.74 | OPRM1 (0.46) | OPRM1DRD3TACR1HTR2AOPRD1 | |
| Hydrochloric Acid SCHEMBL8367126 | 0.73 | DRD3 (0.45) | OPRM1DRD3TACR1HTR2AOPRD1 | |
| SCHEMBL28865491 | 0.73 | OPRM1 (0.48) | OPRM1DRD3TACR1HTR2AOPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4140781-A | Analgesic and neuraleptic 2-piperidinoalkyl-1,4-benzodioxans | CIBA-GEIGY CORPORATION (US) | 1979-02-20 | — | — | US | disclosed |
| US-4129655-A | Neuroleptic 2-piperidinoalkyl-1,4-benzodioxans | CIBA-GEIGY CORPORATION (US) | 1978-12-12 | — | — | US | disclosed |