Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 7/20 | 0.73 |
| ▸ | PARP2 | Q9UGN5 | 7/20 | 0.73 |
| ▸ | PARP15 | Q460N3 | 5/20 | 0.73 |
| ▸ | TNKS2 | Q9H2K2 | 4/20 | 0.73 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.73 |
| ▸ | TNKS | O95271 | 1/20 | 0.73 |
| ▸ | PARP1 | P09874 | 1/20 | 0.73 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.73 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.73 |
| ▸ | PARP12 | Q9H0J9 | 1/20 | 0.73 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.73 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.73 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.73 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11534080 | 0.86 | PARP2 (0.55) | PARP10PARP2PARP15TNKS2PARP14 | |
| SCHEMBL25323961 | 0.85 | PARP10 (1.00) | PARP10PARP2PARP15TNKS2PARP14 | |
| SCHEMBL25918359 | 0.83 | PARP10 (0.69) | PARP10PARP2PARP15TNKS2PARP14 | |
| SCHEMBL11532017 | 0.83 | PARP2 (0.53) | PARP10PARP2PARP15TNKS2PARP14 | |
| SCHEMBL19718859 | 0.81 | PARP10 (0.66) | PARP10PARP2PARP15TNKS2PARP14 | |
| SCHEMBL25324408 | 0.81 | PARP2 (1.00) | PARP10PARP2PARP15TNKS2PARP14 | |
| SCHEMBL15245382 | 0.80 | PARP2 (0.64) | PARP10PARP2PARP15TNKS2PARP14 | |
| SCHEMBL11536976 | 0.79 | CHEK1 (0.66) | PARP10PARP2PARP15TNKS2PARP14 | |
| SCHEMBL11744096 | 0.79 | PARP2 (0.46) | PARP10PARP2PARP15TNKS2PARP14 | |
| Hydrochloric Acid SCHEMBL11747896 | 0.77 | CHEK1 (0.64) | PARP10PARP2PARP15TNKS2PARP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9846160-B2 | Ganglioside GD2 as a marker and target on cancer stem cells | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMS (US) | 2017-12-19 | — | — | US | disclosed |
| US-4134914-A | 1-Acyl-4-substituted phenyl thiosemicarbazides | ELI LILLY AND COMPANY (US) | 1979-01-16 | — | — | US | disclosed |
| US-4082762-A | 4-(2-HALOPHENYL)-1,2,4-TRIAZOLE-3-THIOL COMPOUNDS | ELI LILLY AND COMPANY (US) | 1978-04-04 | — | — | US | disclosed |
| US-3937713-A | Process for the preparation of s-triazolo[3,4-b]benzothiazoles | ELI LILLY AND COMPANY (US) | 1976-02-10 | — | — | US | disclosed |