Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.38 |
| ▸ | CHKA known ✓ | P35790 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 3/20 | 0.35 |
| ▸ | AGXT | P21549 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11533878 | 0.83 | CA1 (0.45) | BCHEACHESMN1; SMN2CA1CA2 | |
| Bromide SCHEMBL11535913 | 0.83 | ALDH1A1 (0.47) | BCHEACHETAAR1CYP11B1CYP11B2 | |
| Bromide SCHEMBL11537233 | 0.83 | LMNA (0.42) | BCHEACHETAAR1CYP11B1CYP11B2 | |
| SCHEMBL11539146 | 0.81 | NPSR1 (0.44) | SMN1; SMN2CA1CA2CHKA | |
| Hydrochloric Acid SCHEMBL11537914 | 0.81 | KDM4E (0.35) | CYP11B1CYP11B2SMN1; SMN2CA1CA2 | |
| Hydrochloric Acid SCHEMBL11539012 | 0.80 | CHKA (0.41) | BCHEACHECYP11B1CYP11B2AGXT | |
| Hydrochloric Acid SCHEMBL11536281 | 0.80 | NPSR1 (0.43) | SMN1; SMN2CA1CA2 | |
| Bromide SCHEMBL11534815 | 0.78 | ACHE (0.50) | BCHEACHESMN1; SMN2 | |
| Bromide SCHEMBL11536307 | 0.77 | LMNA (0.39) | BCHEACHETAAR1IDO1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11540455 | 0.77 | CA1 (0.46) | ACHETAAR1IDO1AGXTMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4163745-A | ANTIDIABETIC, HYPOGLYCEMIC | PFIZER INC. (US) | 1979-08-07 | — | — | US | disclosed |
| US-4141898-A | Imidazo pyridinium quaternary salts as hypoglycemic agents | PFIZER INC. (US) | 1979-02-27 | — | — | US | disclosed |
| US-4129567-A | IMIDAZOPYRIDINES AND ISOB IDINE | PFIZER INC. (US) | 1978-12-12 | — | — | US | disclosed |
| US-4093616-A | PYRROLO(1,2-A)PYRAZINIUM, PYRAZOLO(1,5-A)PYRIDINIUM, 1H-IMIDAZO(2,1-A)ISOQUINOLINIUM, OR IMIDAZO(5,1-A)ISOQUINOLINIUM SALTS | PFIZER INC. (US) | 1978-06-06 | — | — | US | disclosed |
| US-4044015-A | Imidazopyridinium compounds as hypoglycemic agents | PFIZER INC. (US) | 1977-08-23 | — | — | US | disclosed |