Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT1 | Q99873 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 5/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | HTT | P42858 | 4/20 | 0.59 |
| ▸ | BLM | P54132 | 4/20 | 0.59 |
| ▸ | APP | P05067 | 6/20 | 0.58 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | APAF1 | O14727 | 2/20 | 0.58 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.58 |
| ▸ | ALPL | P05186 | 1/20 | 0.58 |
| ▸ | ITGAM | P11215 | 1/20 | 0.58 |
| ▸ | GFER | P55789 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | THRB | P10828 | 2/20 | 0.54 |
| ▸ | PKM | P14618 | 2/20 | 0.54 |
| ▸ | RECQL | P46063 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL10821222 | 0.98 | PRMT1 (0.70) | PRMT1MEN1KMT2AHTTBLM | |
| SCHEMBL9785944 | 0.92 | PRMT1 (0.60) | PRMT1MEN1KMT2AHTTBLM | |
| Iodide SCHEMBL29556031 | 0.82 | PRMT1 (0.76) | PRMT1MEN1KMT2AHTTBLM | |
| Hydrochloric Acid SCHEMBL29556620 | 0.82 | PRMT1 (0.73) | PRMT1MEN1KMT2AHTTBLM | |
| Iodide SCHEMBL9785935 | 0.79 | MEN1 (0.51) | PRMT1MEN1KMT2AHTTBLM | |
| SCHEMBL14984255 | 0.79 | PRMT1 (0.70) | PRMT1MEN1KMT2AHTTBLM | |
| SCHEMBL18070601 | 0.79 | PRMT1 (0.70) | PRMT1MEN1KMT2AHTTBLM | |
| SCHEMBL24327002 | 0.78 | PRMT1 (0.66) | PRMT1MEN1KMT2AHTTBLM | |
| SCHEMBL18070477 | 0.78 | PRMT1 (0.69) | PRMT1MEN1KMT2AHTTBLM | |
| Iodide SCHEMBL29556211 | 0.77 | PRMT1 (0.68) | PRMT1MEN1KMT2AHTTBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE29930-E | HIGH SPEED | EASTMAN KODAK COMPANY (US) | 1979-03-13 | — | — | US | disclosed |
| US-4011081-A | DIRECT-POSITIVE DOUBLE EXPOSURE PROCESS UTILIZING A PRIMITIVE, UNFOGGED SILVER HALIDE EMULSION CONTAINING AN ELECTRON ACCEPTOR | EASTMAN KODAK COMPANY (US) | 1977-03-08 | — | — | US | disclosed |
| US-3970459-A | Process for developing a direct reversal silver halide photographic light-sensitive material | FUJI PHOTO FILM CO., LTD. (JA) | 1976-07-20 | — | — | US | disclosed |